HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18790757, 16365308
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~fn3, fn3~ig, EphA2_TM~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~fn3, PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr
Common GO terms	GO:0004713 - protein tyrosine kinase activity GO:0005524 - ATP binding GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0018108 - peptidyl-tyrosine phosphorylation and 1 others more... GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 986
+	Hs
		601484 FGFR2_HUMAN (1-821): 0: 803: 71.21		EPHA4_HUMAN (1-986): 0: 1293: 100.00
+	Hs
		609225 FGFR3_HUMAN (6-821): 0: 730: 61.22		EPHA4_HUMAN (1-986): 0: 1293: 100.00
+	Hs
		607929 FGFR4_HUMAN (29-808): 0: 664: 55.60		EPHA4_HUMAN (1-986): 0: 1293: 100.00
+	Hs
		665385 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHA4_HUMAN (1-986): 0: 1293: 100.00
+	Hs
		507871 FGFR1_HUMAN (1-822): 0: 861: 100.00		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		607974 FGFR4_HUMAN (29-808): 0: 664: 55.60		EPHA7_HUMAN (5-986): 0: 1212: 62.37
+	Hs
		601465 FGFR2_HUMAN (1-821): 0: 803: 71.21		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		665383 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHA5_HUMAN (2-986): 0: 1201: 63.67
+	Hs
		665374 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHB2_HUMAN (30-983): 0: 1169: 58.47
+	Hs
		609184 FGFR3_HUMAN (6-821): 0: 730: 61.22		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		607887 FGFR4_HUMAN (29-808): 0: 664: 55.60		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		665142 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		665384 EPHA3_HUMAN (3-775): 0: 643: 19.03		EPHB4_HUMAN (14-977): 0: 1028: 49.90
+	Hs
		435514 FGFR1_HUMAN (1-822): 0: 861: 100.00		IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47
+	Hs
		435536 FGFR4_HUMAN (29-808): 0: 664: 55.60		IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47
+	Hs
		507818 FGFR1_HUMAN (1-822): 0: 861: 100.00		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42
+	Hs
		412008 FGFR2_HUMAN (1-821): 0: 803: 71.21		FYN_HUMAN (615-879): 2.51e-66: 234: 44.20
+	Hs
		522773 FGFR2_HUMAN (1-821): 0: 803: 71.21		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42
+	Hs
		412036 EPHA3_HUMAN (3-775): 0: 643: 19.03		FYN_HUMAN (615-879): 2.51e-66: 234: 44.20
+	Hs
		522802 EPHA3_HUMAN (3-775): 0: 643: 19.03		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42