Protein: DLG4
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

Gene: DLG4
Organism: Rattus norvegicus
Interactions: 67
UniProt ID: P31016

Gene Ontology (top 5):
GO:0002091 - negative regulation of receptor internalization
GO:0005102 - signaling receptor binding
GO:0005109 - frizzled binding
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

723905

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

3

14

Small-scale

0.830

High

723890

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]

2

6

Small-scale

0.754

High

723904

SRC
Proto-oncogene tyrosine-protein kinase Src

2

17

Small-scale

0.754

High

723876

NMDE1
Glutamate receptor ionotropic, NMDA 2A

9

20

Small-scale

0.748

High

723877

NMDE2
Glutamate receptor ionotropic, NMDA 2B

8

20

Small-scale

0.747

High

723883

DLG1
Disks large homolog 1

2

17

Small-scale

0.737

High

723871

DLGP1
Disks large-associated protein 1

4

20

Small-scale

0.701

High

723861

NMDZ1
Glutamate receptor ionotropic, NMDA 1

5

20

Small-scale

0.695

High

98912

DGKI
Diacylglycerol kinase iota

1

10

Small-scale

0.691

High

723898

GRASP
General receptor for phosphoinositides 1-associated scaffold protein

1

18

Small-scale

0.690

High

147595

DGKZ
Diacylglycerol kinase zeta

1

10

Small-scale

0.680

High

723869

LRRC7
Leucine-rich repeat-containing protein 7

1

12

Small-scale

0.665

High

723907

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

14

Small-scale

0.665

High

723908

LIN7B
Protein lin-7 homolog B

1

19

Small-scale

0.665

High

723859

MAP1A
Microtubule-associated protein 1A

2

8

Small-scale

0.656

High

723878

NMDE3
Glutamate receptor ionotropic, NMDA 2C

3

20

Small-scale

0.630

High

92888

D3ZDA6
Sidekick cell adhesion molecule 2

1

12

Small-scale

0.621

High

723884

NLGN1
Neuroligin-1

2

19

Small-scale

0.619

High

432379

KPCA
Protein kinase C alpha type

1

10

Small-scale

0.618

High

713178

NOS1
Nitric oxide synthase 1

1

4

Small-scale

0.618

High

723875

GRIP1
Glutamate receptor-interacting protein 1

1

16

Small-scale

0.618

High

723879

LRFN2
Leucine-rich repeat and fibronectin type-III domain-containing protein 2

1

20

Small-scale

0.618

High

723882

PTPRZ
Receptor-type tyrosine-protein phosphatase zeta

1

7

Small-scale

0.618

High

723886

DLG3
Disks large homolog 3

1

17

Small-scale

0.618

High

723891

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

6

Small-scale

0.618

High

723893

TANC1
Protein TANC1

1

13

Small-scale

0.618

High

723902

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

16

Small-scale

0.618

High

723903

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

11

Small-scale

0.618

High

623648

GRIA1
Glutamate receptor 1

2

20

Small-scale

0.588

High

723895

CCG2
Voltage-dependent calcium channel gamma-2 subunit

2

9

Small-scale

0.584

High

97299

CTRO
Citron rho-interacting kinase

1

8

Small-scale

0.575

High

98815

F1LXJ9
protein-tyrosine-phosphatase

1

6

Small-scale

0.575

High

312759

KIF1B
Kinesin-like protein KIF1B

1

19

Small-scale

0.575

High

93112

D3ZVH5
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.561

High

723868

APC
Adenomatous polyposis coli protein

1

18

Small-scale

0.561

High

723892

Q66HJ7
Receptor-type tyrosine-protein phosphatase alpha

1

9

Small-scale

0.561

High

723906

GCYA2
Guanylate cyclase soluble subunit alpha-2

1

9

Small-scale

0.561

High

723872

DLGP2
Disks large-associated protein 2

1

20

Small-scale

0.552

High

704102

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

10

Small-scale

0.543

High

236498

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

Small-scale

0.536

High

723880

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.536

High

633436

GCYB1
Guanylate cyclase soluble subunit beta-1

1

9

Small-scale

0.515

High

723590

SSR4
Somatostatin receptor type 4

1

13

Small-scale

0.515

High

528537

ADRB2
Beta-2 adrenergic receptor

1

17

Small-scale

0.500

High

723885

NLGN2
Neuroligin-2

1

19

Small-scale

0.481

High

92959

D3ZK41
SLIT and NTRK-like family, member 2

1

15

Small-scale

0.479

High

583946

KCNA4
Potassium voltage-gated channel subfamily A member 4

1

20

Small-scale

0.479

High

723860

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

9

Small-scale

0.479

High

723862

GRIK2
Glutamate receptor ionotropic, kainate 2

1

20

Small-scale

0.479

High

723863

P2RY1
P2Y purinoceptor 1

1

18

Small-scale

0.479

High

723864

EAA3
Excitatory amino acid transporter 3

1

4

Small-scale

0.479

High

723867

MK01
Mitogen-activated protein kinase 1

1

9

High-throughput

0.479

High

723887

ARC
Activity-regulated cytoskeleton-associated protein

1

2

Small-scale

0.479

High

723896

CRIPT
Cysteine-rich PDZ-binding protein

1

3

Small-scale

0.479

High

723897

KLH17
Kelch-like protein 17

1

4

Small-scale

0.479

High

723899

CCG8
Voltage-dependent calcium channel gamma-8 subunit

1

8

Small-scale

0.479

High

723900

Q99PR9
Voltage-dependent calcium channel gamma-2 subunit

1

8

Small-scale

0.479

High

723894

WIPF1
WAS/WASL-interacting protein family member 1

1

3

Small-scale

0.470

High

723901

SHRPN
Sharpin

1

0

Small-scale

0.458

High

723866

STXB1
Syntaxin-binding protein 1

1

2

Small-scale

0.457

High

723873

DLGP3
Disks large-associated protein 3

1

20

Small-scale

0.457

High

723874

DLGP4
Disks large-associated protein 4

1

20

Small-scale

0.457

High

723881

NMDE4
Glutamate receptor ionotropic, NMDA 2D

1

20

Small-scale

0.457

High

723888

GRID2
Glutamate receptor ionotropic, delta-2

1

20

Small-scale

0.457

High

723865

KCJ12
ATP-sensitive inward rectifier potassium channel 12

1

20

Small-scale

0.445

High

723870

VANG2
Vang-like protein 2

1

6

Small-scale

0.445

High

723889

NRX2A
Neurexin-2

1

20

Small-scale

0.445

High


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Last updated: 11Aug2025