HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	18022941, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0001525 - angiogenesis GO:0005829 - cytosol GO:0043536 - positive regulation of blood vessel endothelial cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 694
+	Hs
		607961 FGFR4_HUMAN (29-808): 0: 664: 55.60		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665596 EPHB2_HUMAN (4-819): 0: 640: 18.07		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		872436 EPHA5_HUMAN (3-791): 0: 639: 19.15		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		872642 EPHA4_HUMAN (3-783): 0: 620: 19.44		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665234 EPHA2_HUMAN (3-819): 0: 583: 18.68		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		508062 FGFR1_HUMAN (1-822): 0: 861: 100.00		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		508203 FGFR1_HUMAN (1-822): 0: 861: 100.00		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		1035376 NTRK2_HUMAN (102-762): 5.62e-163: 495: 22.70		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		546325 NTRK2_MOUSE (111-762): 1.43e-163: 497: 23.74		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		508205 FGFR1_HUMAN (1-822): 0: 861: 100.00		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		608137 FGFR4_HUMAN (29-808): 0: 664: 55.60		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		609340 FGFR3_HUMAN (6-821): 0: 730: 61.22		PKHS1_HUMAN (5-310): 1.59e-42: 162: 17.13
+	Hs
		665661 EPHB2_HUMAN (4-819): 0: 640: 18.07		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		872491 EPHA5_HUMAN (3-791): 0: 639: 19.15		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		1072602 EPHA7_HUMAN (3-783): 0: 629: 19.40		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		608139 FGFR4_HUMAN (29-808): 0: 664: 55.60		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		665662 EPHB2_HUMAN (4-819): 0: 640: 18.07		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		872492 EPHA5_HUMAN (3-791): 0: 639: 19.15		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		1072603 EPHA7_HUMAN (3-783): 0: 629: 19.40		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		872712 EPHA4_HUMAN (3-783): 0: 620: 19.44		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49