HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: SH319 (Q5HYK7)
SH3 domain-containing protein 19 (ADAM-binding protein Eve-1) (EEN-binding protein) (EBP)
Gene: SH3D19

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH3_1, PK_Tyr_Ser-Thr~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 790
+	Hs
		608000 FGFR4_HUMAN (29-808): 0: 664: 55.60		SH319_HUMAN (1-790): 3.57e-99: 327: 100.00
+	Hs
		508022 FGFR1_HUMAN (1-822): 0: 861: 100.00		ITSN1_HUMAN (417-786): 3.11e-27: 121: 18.20
+	Hs
		507832 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		208983 FGFR1_HUMAN (1-822): 0: 861: 100.00		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		507939 FGFR1_HUMAN (1-822): 0: 861: 100.00		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		508233 FGFR1_HUMAN (1-822): 0: 861: 100.00		ITSN2_HUMAN (680-790): 7.11e-16: 84.4: 24.78
+	Hs
		508140 FGFR1_HUMAN (1-822): 0: 861: 100.00		SH3K1_HUMAN (477-670): 2.62e-10: 65.9: 14.72
+	Hs
		601492 FGFR2_HUMAN (1-821): 0: 803: 71.21		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		601605 FGFR2_HUMAN (1-821): 0: 803: 71.21		ITSN2_HUMAN (680-790): 7.11e-16: 84.4: 24.78
+	Hs
		609244 FGFR3_HUMAN (6-821): 0: 730: 61.22		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		607984 FGFR4_HUMAN (29-808): 0: 664: 55.60		ITSN1_HUMAN (417-786): 3.11e-27: 121: 18.20
+	Hs
		557606 FGFR4_HUMAN (29-808): 0: 664: 55.60		NCK1_HUMAN (414-659): 8.08e-29: 120: 19.93
+	Hs
		208993 FGFR4_HUMAN (29-808): 0: 664: 55.60		NCK2_HUMAN (414-652): 5.41e-28: 118: 20.36
+	Hs
		607935 FGFR4_HUMAN (29-808): 0: 664: 55.60		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		608159 FGFR4_HUMAN (29-808): 0: 664: 55.60		ITSN2_HUMAN (680-790): 7.11e-16: 84.4: 24.78
+	Hs
		665389 EPHA3_HUMAN (3-775): 0: 643: 19.03		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Hs
		665574 EPHB2_HUMAN (4-819): 0: 640: 18.07		GRB2_HUMAN (498-718): 1.8e-24: 104: 20.27
+	Mm
		872621 EPHB2_MOUSE (4-819): 0: 640: 17.95		GRB2_MOUSE (498-718): 2.72e-24: 103: 20.27
+	Hs
		608026 FGFR4_HUMAN (29-808): 0: 664: 55.60		SH3R1_HUMAN (244-550): 1.54e-09: 63.7: 11.61
+	Hs
		608105 FGFR4_HUMAN (29-808): 0: 664: 55.60		SRBS1_HUMAN (672-788): 2.98e-09: 62.8: 33.07