HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: SCYL2 (Q6P3W7)
SCY1-like protein 2 (Coated vesicle-associated kinase of 104 kDa)
Gene: SCYL2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 929
+	Hs
		601532 FGFR2_HUMAN (1-821): 0: 803: 71.21		SCYL2_HUMAN (1-929): 0: 699: 99.14
+	Hs
		609358 FGFR3_HUMAN (6-821): 0: 730: 61.22		SCYL2_HUMAN (1-929): 0: 699: 99.14
+	Hs
		608015 FGFR4_HUMAN (29-808): 0: 664: 55.60		SCYL2_HUMAN (1-929): 0: 699: 99.14
+	Hs
		508016 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A1_HUMAN (3-717): 3.6e-138: 432: 12.25
+	Hs
		507919 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A3_HUMAN (3-717): 1.11e-135: 425: 12.27
+	Hs
		508015 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A2_HUMAN (7-722): 1.93e-133: 419: 12.80
+	Rn
		979772 FGFR1_RAT (1-822): 0: 849: 97.69		KS6A1_RAT (3-717): 2.4e-137: 429: 11.98
+	Hs
		601517 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A1_HUMAN (3-717): 3.6e-138: 432: 12.25
+	Hs
		601482 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A3_HUMAN (3-717): 1.11e-135: 425: 12.27
+	Hs
		601516 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A2_HUMAN (7-722): 1.93e-133: 419: 12.80
+	Hs
		609219 FGFR3_HUMAN (6-821): 0: 730: 61.22		KS6A3_HUMAN (3-717): 1.11e-135: 425: 12.27
+	Hs
		385016 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		SCYL2_HUMAN (1-929): 0: 699: 99.14
+	Hs
		607975 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A1_HUMAN (3-717): 3.6e-138: 432: 12.25
+	Hs
		607926 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A3_HUMAN (3-717): 1.11e-135: 425: 12.27
+	Hs
		608180 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A6_HUMAN (6-678): 1.34e-126: 402: 12.47
+	Hs
		665243 EPHA2_HUMAN (3-819): 0: 583: 18.68		KS6A2_HUMAN (7-722): 1.93e-133: 419: 12.80
+	Hs
		384892 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		KS6A1_HUMAN (3-717): 3.6e-138: 432: 12.25
+	Hs
		384525 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		KS6A3_HUMAN (3-717): 1.11e-135: 425: 12.27
+	Hs
		385358 NTRK1_HUMAN (122-769): 8.92e-140: 434: 25.96		SCYL1_HUMAN (32-807): 9.42e-131: 414: 17.22
+	Hs
		160396 EPHA2_HUMAN (3-819): 0: 583: 18.68		AURKA_HUMAN (28-326): 7.69e-63: 220: 24.42