Protein: GPS2
G protein pathway suppressor 2 (GPS-2)

Gene: GPS2
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q13227

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity
GO:0005095 - GTPase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

261496

NCOR1
Nuclear receptor corepressor 1

6

2

Small-scale

0.950

High

1028223

NCOR2
Nuclear receptor corepressor 2

5

2

Small-scale

0.937

High

177282

HDAC3
Histone deacetylase 3

10

1

Small-scale

0.758

High

245598

TBL1X
F-box-like/WD repeat-containing protein TBL1X

7

2

Small-scale

0.755

High

579261

ATF4
Cyclic AMP-dependent transcription factor ATF-4

5

1

High-throughput

0.726

High

1028161

RBP1
RalA-binding protein 1

8

0

High-throughput

0.720

High

952803

FOXK1
Forkhead box protein K1

4

2

High-throughput

0.699

High

1028204

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

4

2

High-throughput

0.699

High

1028162

K1H1
Keratin, type I cuticular Ha1

3

2

High-throughput

0.678

High

212311

CYH3
Cytohesin-3

3

1

High-throughput

0.667

High

255243

LIPA3
Liprin-alpha-3

3

1

High-throughput

0.667

High

647565

MK03
Mitogen-activated protein kinase 3

3

1

High-throughput

0.667

High

964174

FOXK2
Forkhead box protein K2

3

2

High-throughput

0.667

High

1025278

LIPA1
Liprin-alpha-1

3

1

High-throughput

0.667

High

1028177

ANR11
Ankyrin repeat domain-containing protein 11

3

1

High-throughput

0.667

High

1028213

TFP11
Tuftelin-interacting protein 11

3

0

High-throughput

0.646

High

126687

DCTN6
Dynactin subunit 6

3

0

High-throughput

0.638

High

200111

DAPK3
Death-associated protein kinase 3

3

0

High-throughput

0.638

High

278605

DCTN3
Dynactin subunit 3

3

0

High-throughput

0.638

High

1028175

TRI68
E3 ubiquitin-protein ligase TRIM68

3

0

High-throughput

0.638

High

1028186

ARMC8
Armadillo repeat-containing protein 8

3

0

High-throughput

0.638

High

1028211

ARP10
Actin-related protein 10

3

0

High-throughput

0.638

High

1028200

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

2

High-throughput

0.628

High

1028180

MAEA
E3 ubiquitin-protein transferase MAEA

2

3

High-throughput

0.611

High

1028210

GID8
Glucose-induced degradation protein 8 homolog

2

3

High-throughput

0.611

High

280575

KRT34
Keratin, type I cuticular Ha4

2

2

High-throughput

0.606

High

280793

KRT36
Keratin, type I cuticular Ha6

2

2

High-throughput

0.606

High

1028182

K1C27
Keratin, type I cytoskeletal 27

2

2

High-throughput

0.606

High

1028202

KRA33
Keratin-associated protein 3-3

2

1

High-throughput

0.606

High

1028203

KRA31
Keratin-associated protein 3-1

2

1

High-throughput

0.606

High

1028221

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

1

High-throughput

0.606

High

1028156

HDAC1
Histone deacetylase 1

1

1

Small-scale

0.586

High

179983

MSH4
MutS protein homolog 4

1

1

Small-scale

0.586

High

198154

MSH5
MutS protein homolog 5

1

1

Small-scale

0.586

High

556857

CREB1
Cyclic AMP-responsive element-binding protein 1

2

0

High-throughput

0.585

High

1028217

DCTN4
Dynactin subunit 4

2

0

High-throughput

0.585

High

1028218

MKLN1
Muskelin

2

0

High-throughput

0.585

High

782536

HNF4A
Hepatocyte nuclear factor 4-alpha

2

1

Small-scale

0.584

High

1028220

HDAC5
Histone deacetylase 5

2

3

Small-scale

0.584

High

204316

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

314037

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

682792

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

0

High-throughput

0.580

High

829844

HXA1
Homeobox protein Hox-A1

2

0

High-throughput

0.580

High

1028159

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1028165

TRIP6
Thyroid receptor-interacting protein 6

2

0

High-throughput

0.580

High

1028166

OBF1
POU domain class 2-associating factor 1

2

0

High-throughput

0.580

High

1028167

KRA61
Keratin-associated protein 6-1

2

0

High-throughput

0.580

High

1028168

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.580

High

1028170

KR132
Keratin-associated protein 13-2

2

0

High-throughput

0.580

High

1028171

SMUG1
Single-strand selective monofunctional uracil DNA glycosylase

2

0

High-throughput

0.580

High

1028173

INT11
Integrator complex subunit 11

2

0

High-throughput

0.580

High

1028174

FHL5
Four and a half LIM domains protein 5

2

0

High-throughput

0.580

High

1028185

KR111
Keratin-associated protein 11-1

2

0

High-throughput

0.580

High

1028214

NDOR1
NADPH-dependent diflavin oxidoreductase 1

2

0

High-throughput

0.580

High

1028219

AKP8L
A-kinase anchor protein 8-like

2

0

High-throughput

0.580

High

1028164

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

2

Small-scale

0.561

High

883453

M3KCL
MAP3K7 C-terminal-like protein

1

0

High-throughput

0.558

High

60572

VP37C
Vacuolar protein sorting-associated protein 37C

2

1

High-throughput

0.553

High

943781

CCNA1
Cyclin-A1

1

0

Small-scale

0.549

High

1028191

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.549

High

1028193

SPDLY
Protein Spindly

1

1

High-throughput

0.541

High

386656

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

998644

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.537

High

658924

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.536

High

1028163

CYH1
Cytohesin-1

1

1

High-throughput

0.536

High

1028176

ANR12
Ankyrin repeat domain-containing protein 12

1

1

High-throughput

0.536

High

1028209

EMAL4
Echinoderm microtubule-associated protein-like 4

1

1

High-throughput

0.536

High

1018453

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.518

High

1028160

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.518

High

1028194

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.518

High

985541

Q05BL1
TP53BP2 protein

1

1

High-throughput

0.515

High

785534

ACTY
Beta-centractin

1

0

High-throughput

0.513

High

1028215

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.513

High

1028169

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.493

High

1028212

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

Small-scale

0.486

High

1028158

ASPP2
Apoptosis-stimulating of p53 protein 2

1

1

High-throughput

0.481

High

1028195

ANM6
Protein arginine N-methyltransferase 6

1

0

Small-scale

0.480

High

130324

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

1

Small-scale

0.479

High

225738

SOX15
Transcription factor SOX-15

1

3

High-throughput

0.479

High

318615

EYA4
Eyes absent homolog 4

1

1

High-throughput

0.479

High

443183

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

487394

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

500414

THA
Thyroid hormone receptor alpha

1

4

Small-scale

0.479

High

500480

THB
Thyroid hormone receptor beta

1

4

Small-scale

0.479

High

620150

PAX7
Paired box protein Pax-7

1

5

High-throughput

0.479

High

641398

PAX6
Paired box protein Pax-6

1

4

High-throughput

0.479

High

727516

HNF1B
Hepatocyte nuclear factor 1-beta

1

4

High-throughput

0.479

High

740517

PPARG
Peroxisome proliferator-activated receptor gamma

1

3

High-throughput

0.479

High

818008

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

878404

PAX9
Paired box protein Pax-9

1

4

High-throughput

0.479

High

880712

HDAC4
Histone deacetylase 4

1

3

High-throughput

0.479

High

881801

SOX10
Transcription factor SOX-10

1

3

High-throughput

0.479

High

973848

PAX2
Paired box protein Pax-2

1

4

High-throughput

0.479

High

980744

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

988758

PAX8
Paired box protein Pax-8

1

4

High-throughput

0.479

High

1018219

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.479

High

1021276

FOXL1
Forkhead box protein L1

1

2

High-throughput

0.479

High

1028178

RBP10
Ran-binding protein 10

1

1

High-throughput

0.479

High

1028197

NR1H4
Bile acid receptor

1

4

Small-scale

0.479

High

1028205

SOX17
Transcription factor SOX-17

1

3

High-throughput

0.479

High

1028207

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

2

High-throughput

0.479

High

1028208

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.479

High

123930

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.458

High

162695

XPO1
Exportin-1

1

0

High-throughput

0.458

High

171027

TBXT
T-box transcription factor T

1

0

High-throughput

0.458

High

346686

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

798884

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

831284

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

838804

EMD
Emerin

1

0

Small-scale

0.458

High

884149

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.458

High

914861

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.458

High

917206

H4
Histone H4

1

0

High-throughput

0.458

High

1028157

CUL4B
Cullin-4B

1

0

Small-scale

0.458

High

1028181

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1028183

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

1028189

SP7
Transcription factor Sp7

1

0

High-throughput

0.458

High

1028192

LHX4
LIM/homeobox protein Lhx4

1

0

High-throughput

0.458

High

1028198

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

1028206

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1028216

DBNL
Drebrin-like protein

1

0

High-throughput

0.458

High

1028222

NINL
Ninein-like protein

1

0

High-throughput

0.458

High

1028196

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.438

High

1028199

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.426

High

1028184

SESD1
SEC14 domain and spectrin repeat-containing protein 1

4

0

High-throughput

0.364

High

1028187

GID4
Glucose-induced degradation protein 4 homolog

3

0

High-throughput

0.347

High

49949

F168B
Myelin-associated neurite-outgrowth inhibitor

2

0

High-throughput

0.316

High

67061

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1028172

ACTMP
Actin maturation protease

2

0

High-throughput

0.316

High

1028190

UBTD2
Ubiquitin domain-containing protein 2

2

0

High-throughput

0.316

High

994848

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.282

High

1012445

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.282

High

1028179

WDR87
WD repeat-containing protein 87

1

0

High-throughput

0.279

Low

1028188

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

1028201

TDRD1
Tudor domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024