HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: FGF23 (Q9GZV9)
Fibroblast growth factor 23 (FGF-23) (Phosphatonin) (Tumor-derived hypophosphatemia-inducing factor) [Cleaved into: Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide]
Gene: FGF23

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.77 1.00 0.878

The method score is based on:

Property Details
Experiments 27879395, 22393163, 19966287, 17086194
Identification Methods affinity chromatography technology, surface plasmon resonance, pull down
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains FGF~I-set
Common GO terms GO:0005576 - extracellular region
GO:0008284 - positive regulation of cell population proliferation
GO:0008543 - fibroblast growth factor receptor signaling pathway
GO:0010966 - regulation of phosphate transport
GO:0055074 - calcium ion homeostasis
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 822
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024