HitPredict

Interactor 1: FGFR1 (P11362)
Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331)
Gene: FGFR1

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0000165 - MAPK cascade GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0006468 - protein phosphorylation and 1 others more... GO:0046777 - protein autophosphorylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 822 Hs			1 1360
+	Hs
		508100 FGFR1_HUMAN (1-822): 0: 861: 100.00		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		608181 FGFR4_HUMAN (29-808): 0: 664: 55.60		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		665680 EPHB2_HUMAN (4-819): 0: 640: 18.07		TNIK_HUMAN (1-1360): 0: 1235: 100.00
+	Hs
		324728 FGFR1_HUMAN (1-822): 0: 861: 100.00		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		324739 FGFR4_HUMAN (29-808): 0: 664: 55.60		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		324742 EPHB2_HUMAN (4-819): 0: 640: 18.07		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		508015 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		507919 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		507867 FGFR1_HUMAN (1-822): 0: 861: 100.00		MARK3_HUMAN (3-675): 1.72e-124: 406: 16.37
+	Hs
		601516 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		601482 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		508016 FGFR1_HUMAN (1-822): 0: 861: 100.00		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Rn
		979772 FGFR1_RAT (1-822): 0: 849: 97.69		KS6A1_RAT (1-350): 3.49e-98: 333: 22.95
+	Hs
		609219 FGFR3_HUMAN (6-821): 0: 730: 61.22		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		601517 FGFR2_HUMAN (1-821): 0: 803: 71.21		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Hs
		508290 FGFR1_HUMAN (1-822): 0: 861: 100.00		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Hs
		607926 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A3_HUMAN (10-709): 1.25e-135: 435: 16.74
+	Hs
		608180 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A6_HUMAN (10-709): 1.13e-130: 422: 16.27
+	Hs
		647831 EPHB2_HUMAN (4-819): 0: 640: 18.07		MARK3_HUMAN (3-675): 1.72e-124: 406: 16.37
+	Hs
		607975 FGFR4_HUMAN (29-808): 0: 664: 55.60		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63