HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 0.60 0.612

The method score is based on:

Property Details
Experiments 35271311, 15848144
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001673 - male germ cell nucleus
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005524 - ATP binding
and 7 others

more...
Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 765
Hs

1 1531
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024