Protein: ZNRF1
E3 ubiquitin-protein ligase ZNRF1 (EC 2.3.2.27) (Nerve injury-induced gene 283 protein) (RING-type E3 ubiquitin transferase ZNRF1) (Zinc/RING finger protein 1)

Gene: ZNRF1
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q8ND25

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0005768 - endosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957793

UBE2N
Ubiquitin-conjugating enzyme E2 N

6

20

Small-scale

0.962

High

906709

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.937

High

982250

UB2D2
Ubiquitin-conjugating enzyme E2 D2

5

20

Small-scale

0.937

High

1336243

UB2D4
Ubiquitin-conjugating enzyme E2 D4

4

20

High-throughput

0.904

High

957136

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

High-throughput

0.862

High

909353

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

High-throughput

0.843

High

1336241

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

19

Small-scale

0.800

High

1336242

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.791

High

508292

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

2

Small-scale

0.778

High

883285

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

12

High-throughput

0.710

High

1103918

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1154277

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

High-throughput

0.698

High

1336239

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

507283

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.691

High

251462

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

3

1

High-throughput

0.667

High

1336235

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

1

High-throughput

0.647

High

1336240

FBXW5
F-box/WD repeat-containing protein 5

3

0

High-throughput

0.638

High

1336236

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

1

Small-scale

0.618

High

1244883

NCEH1
Neutral cholesterol ester hydrolase 1

2

0

High-throughput

0.585

High

1335478

SEN2
tRNA-splicing endonuclease subunit Sen2

2

0

High-throughput

0.585

High

320726

UBXN7
UBX domain-containing protein 7

2

0

High-throughput

0.580

High

1256345

AN13D
Ankyrin repeat domain-containing protein 13D

1

3

High-throughput

0.536

High

1315813

AN13A
Ankyrin repeat domain-containing protein 13A

1

4

High-throughput

0.536

High

922470

CLH2
Clathrin heavy chain 2

1

0

High-throughput

0.513

High

999386

HBB
Hemoglobin subunit beta

1

0

High-throughput

0.513

High

420623

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

Small-scale

0.501

High

691257

1433T
14-3-3 protein theta

1

3

Small-scale

0.479

High

719643

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

1

High-throughput

0.479

High

899668

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

3

Small-scale

0.479

High

578685

GLNA
Glutamine synthetase

1

0

Small-scale

0.458

High

1041180

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

1207077

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1336237

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1336238

BHMT1
Betaine--homocysteine S-methyltransferase 1

1

0

High-throughput

0.458

High

1280117

SEN54
tRNA-splicing endonuclease subunit Sen54

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025