HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: SFPQ (P23246)
Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor)
Gene: SFPQ

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.697

Property	Details
Experiments	24981860, 9756848, 35271311, 15848144
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003682 - chromatin binding GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0006338 - chromatin remodeling
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 707
+	Hs
		508538 TOP1_HUMAN (1-765): 0: 932: 100.00		NONO_HUMAN (265-707): 1.49e-70: 239: 56.98
+	Hs
		508631 TOP1_HUMAN (1-765): 0: 932: 100.00		PSPC1_HUMAN (230-707): 1.7e-60: 213: 51.96
+	Hs
		508683 TOP1_HUMAN (1-765): 0: 932: 100.00		RBM4B_HUMAN (298-436): 1.27e-40: 154: 27.97
+	Hs
		508691 TOP1_HUMAN (1-765): 0: 932: 100.00		RBM4_HUMAN (298-436): 1.19e-40: 154: 27.97
+	Sc
		376565 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		PABP_YEAST (293-687): 2.32e-69: 239: 15.84
+	Hs
		1069707 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		NONO_HUMAN (265-707): 1.49e-70: 239: 56.98