HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: MCM3 (P25205)
DNA replication licensing factor MCM3 (EC 3.6.4.12) (DNA polymerase alpha holoenzyme-associated protein P1) (P1-MCM3) (RLF subunit beta) (p102)
Gene: MCM3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003697 - single-stranded DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 808
+	Hs
		508395 TOP1_HUMAN (1-765): 0: 932: 100.00		MCM2_HUMAN (10-721): 0: 707: 30.62
+	Hs
		508526 TOP1_HUMAN (1-765): 0: 932: 100.00		MCM6_HUMAN (2-800): 0: 688: 26.50
+	Hs
		508360 TOP1_HUMAN (1-765): 0: 932: 100.00		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Hs
		508359 TOP1_HUMAN (1-765): 0: 932: 100.00		MCM4_HUMAN (9-739): 0: 661: 28.03
+	Hs
		508361 TOP1_HUMAN (1-765): 0: 932: 100.00		MCM7_HUMAN (10-669): 0: 650: 31.62
+	Hs
		708721 TOP1M_HUMAN (183-765): 0: 871: 68.72		MCM5_HUMAN (9-713): 0: 685: 28.92
+	Sc
		388089 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		MCM4_YEAST (9-804): 0: 654: 27.82