HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.715

Property	Details
Experiments	9611241, 12270705, 15848144, 20805487, 17481653
Identification Methods	far western blotting, pull down, affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 248
+	Hs
		508499 TOP1_HUMAN (1-765): 0: 932: 100.00		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Sc
		376565 TOP1_YEAST (600-765): 7.36e-26: 115: 34.88		PABP_YEAST (123-203): 2.42e-12: 68.1: 22.73
+	Hs
		1084347 DC2I1_HUMAN (12-216): 5.31e-09: 62: 13.25		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22