HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: DDX23 (Q9BUQ8)
Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD)
Gene: DDX23

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	34079125, 35271311, 15848144
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 820
+	Hs
		508643 TOP1_HUMAN (1-765): 0: 932: 100.00		DDX17_HUMAN (337-820): 5.87e-132: 412: 34.97
+	Hs
		508324 TOP1_HUMAN (1-765): 0: 932: 100.00		DDX5_HUMAN (297-801): 3.08e-129: 401: 32.81
+	Hs
		1246362 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		DDX23_HUMAN (1-820): 5.19e-160: 488: 100.00
+	Hs
		1154061 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		DDX17_HUMAN (337-820): 5.87e-132: 412: 34.97
+	Hs
		1246384 THOC2_HUMAN (7-198): 3.62e-09: 62.4: 16.42		DDX41_HUMAN (365-795): 7.12e-81: 273: 39.32