Protein: PLS4
Phospholipid scramblase 4 (PL scramblase 4) (Ca(2+)-dependent phospholipid scramblase 4) (Cell growth-inhibiting gene 43 protein) (TRA1)

Gene: PLS4, PLSCR4
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9NRQ2

Gene Ontology (top 5):
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0017121 - plasma membrane phospholipid scrambling
GO:0017124 - SH3 domain binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1151089

PCH2
Pachytene checkpoint protein 2 homolog

3

1

High-throughput

0.667

High

654560

FBLN1
Fibulin-1

3

3

High-throughput

0.667

High

1205998

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

0

High-throughput

0.643

High

1277422

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.628

High

1307653

ZDH17
Palmitoyltransferase ZDHHC17

3

1

High-throughput

0.609

High

180601

PLS1
Phospholipid scramblase 1

2

4

High-throughput

0.608

High

165199

TSN4
Tetraspanin-4

2

1

High-throughput

0.606

High

507384

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

2

High-throughput

0.606

High

508689

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

2

High-throughput

0.606

High

592702

ITB4
Integrin beta-4

2

1

High-throughput

0.606

High

885427

HXA1
Homeobox protein Hox-A1

2

5

High-throughput

0.606

High

987232

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

2

High-throughput

0.606

High

987483

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

2

High-throughput

0.606

High

1139143

DAZP2
DAZ-associated protein 2

2

1

High-throughput

0.606

High

1157202

S15A2
Solute carrier family 15 member 2

2

1

High-throughput

0.606

High

1215018

INT11
Integrator complex subunit 11

2

1

High-throughput

0.606

High

1351666

OXER1
Oxoeicosanoid receptor 1

2

1

High-throughput

0.606

High

1413542

RAMAC
RNA guanine-N7 methyltransferase activating subunit

2

1

High-throughput

0.606

High

1448763

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

1

High-throughput

0.606

High

590499

GATA1
Erythroid transcription factor

2

0

High-throughput

0.580

High

1236159

TEN4
Teneurin-4

2

0

High-throughput

0.580

High

1372095

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.580

High

1397789

TEKT5
Tektin-5

2

0

High-throughput

0.580

High

1412499

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

2

0

High-throughput

0.580

High

1186607

KRA61
Keratin-associated protein 6-1

2

1

High-throughput

0.561

High

159101

LCE2B
Late cornified envelope protein 2B

2

1

High-throughput

0.553

High

950699

KR108
Keratin-associated protein 10-8

2

11

High-throughput

0.553

High

1186863

KR196
Keratin-associated protein 19-6

2

1

High-throughput

0.553

High

1187928

KR197
Keratin-associated protein 19-7

2

1

High-throughput

0.553

High

1213927

LCE1C
Late cornified envelope protein 1C

2

1

High-throughput

0.553

High

1214289

LCE1A
Late cornified envelope protein 1A

2

1

High-throughput

0.553

High

1215961

LCE5A
Late cornified envelope protein 5A

2

2

High-throughput

0.553

High

1250325

ATL4
ADAMTS-like protein 4

2

3

High-throughput

0.553

High

1311478

TRI42
Tripartite motif-containing protein 42

2

1

High-throughput

0.553

High

1419096

KRA42
Keratin-associated protein 4-2

2

11

High-throughput

0.553

High

1419113

KRA33
Keratin-associated protein 3-3

2

3

High-throughput

0.553

High

1419138

KRA31
Keratin-associated protein 3-1

2

3

High-throughput

0.553

High

1419154

KRA15
Keratin-associated protein 1-5

2

11

High-throughput

0.553

High

351608

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

5

High-throughput

0.541

High

1308337

Q8IV28
Nidogen-2

1

1

High-throughput

0.515

High

253987

LPXN
Leupaxin

1

1

High-throughput

0.508

High

1410103

KR412
Keratin-associated protein 4-12

1

12

High-throughput

0.494

High

1307559

ZDH13
Palmitoyltransferase ZDHHC13

1

1

High-throughput

0.489

High

155698

FCHO1
F-BAR domain only protein 1

1

1

High-throughput

0.481

High

1120554

NID2
Nidogen-2

1

1

High-throughput

0.481

High

276529

PDCD6
Programmed cell death protein 6

1

1

Small-scale

0.479

High

374956

RASH
GTPase HRas

1

6

High-throughput

0.479

High

1047872

TLE1
Transducin-like enhancer protein 1

1

1

High-throughput

0.479

High

2825

A0A0C3SFZ9
FCH and mu domain containing endocytic adaptor 1

1

1

High-throughput

0.470

High

192136

PA2GX
Group 10 secretory phospholipase A2

1

0

High-throughput

0.460

High

1315916

ZNF34
Zinc finger protein 34

1

0

High-throughput

0.460

High

1392378

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.460

High

1334971

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1448761

RUVB2
RuvB-like 2

1

1

High-throughput

0.445

High

1448762

RUVB1
RuvB-like 1

1

1

High-throughput

0.445

High

379403

IGHG2
Immunoglobulin heavy constant gamma 2

1

0

High-throughput

0.426

High

1419894

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

2

0

High-throughput

0.318

High

532146

RET3
Retinol-binding protein 3

2

0

High-throughput

0.316

High

654466

EST1
Liver carboxylesterase 1

2

0

High-throughput

0.316

High

1162578

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.316

High

1180825

KLH38
Kelch-like protein 38

2

0

High-throughput

0.316

High

1186557

KR212
Keratin-associated protein 21-2

2

0

High-throughput

0.316

High

1186714

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1186921

KR195
Keratin-associated protein 19-5

2

0

High-throughput

0.316

High

1213846

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.316

High

1307018

KR191
Keratin-associated protein 19-1

2

0

High-throughput

0.316

High

1307098

KRA81
Keratin-associated protein 8-1

2

0

High-throughput

0.316

High

1369112

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

0

High-throughput

0.316

High

1386893

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.316

High

1434576

CFA68
Cilia- and flagella-associated protein 68

2

0

High-throughput

0.316

High

1448757

KRT82
Keratin, type II cuticular Hb2

2

0

High-throughput

0.316

High

1448759

CRCT1
Cysteine-rich C-terminal protein 1

2

0

High-throughput

0.316

High

366216

HPT
Haptoglobin

1

0

High-throughput

0.279

Low

723966

LCN1
Lipocalin-1

1

0

High-throughput

0.279

Low

1349339

TBC15
TBC1 domain family member 15

1

0

High-throughput

0.279

Low

1445952

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

0

High-throughput

0.279

Low

1186809

KRA63
Keratin-associated protein 6-3

1

0

High-throughput

0.268

Low

1218668

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.268

Low

959536

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

1356092

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

0

High-throughput

0.251

Low

1448760

APEL
Apelin

1

0

High-throughput

0.251

Low

1241245

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.238

Low

1448758

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025