HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: SFR19 (Q9H7N4)
Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)
Gene: SCAF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0019904 - protein domain specific binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 765 Hs			1 1312
+	Hs
		508676 TOP1_HUMAN (1-765): 0: 932: 100.00		SCAFB_HUMAN (53-1289): 2.43e-44: 178: 13.25
+	Hs
		508571 TOP1_HUMAN (1-765): 0: 932: 100.00		NIPBL_HUMAN (92-1112): 3.58e-23: 109: 11.69
+	Hs
		508777 TOP1_HUMAN (1-765): 0: 932: 100.00		SRRM2_HUMAN (450-1311): 6.2e-14: 79.5: 12.17
+	Hs
		508507 TOP1_HUMAN (1-765): 0: 932: 100.00		PRP4K_HUMAN (514-804): 6.19e-11: 69.2: 20.82
+	Hs
		1154038 NIPBL_HUMAN (5-216): 7.71e-09: 61.7: 10.92		NIPBL_HUMAN (92-1112): 3.58e-23: 109: 11.69