HitPredict

Interactor 1: TOP2A (P11388)
DNA topoisomerase 2-alpha (EC 5.6.2.2) (DNA topoisomerase II, alpha isozyme)
Gene: TOP2A

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	36089195, 20504901
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0046982 - protein heterodimerization activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1531 Hs			1 136
+	Hs
		508935 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		509016 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		508870 TOP2A_HUMAN (1-1531): 0: 1750: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		934678 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952283 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		973351 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		828199 TOP2B_HUMAN (14-1523): 0: 1644: 65.85		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Sc
		420155 TOP2_YEAST (24-1404): 0: 1262: 41.63		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Sc
		420113 TOP2_YEAST (24-1404): 0: 1262: 41.63		CENPA_YEAST (18-134): 3.39e-40: 135: 56.67