HitPredict

Interactor 1: PYC (P11498)
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)
Gene: PC

Interactor 2: PYC (P11498)
Pyruvate carboxylase, mitochondrial (EC 6.4.1.1) (Pyruvic carboxylase) (PCB)
Gene: PC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.65 1.00 0.812

The method score is based on:

Property Details
Experiments 18297087, 34547241
Identification Methods molecular sieving, light scattering, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Biotin_carb_C~Biotin_carb_C, Biotin_carb_C~Biotin_carb_N, Biotin_carb_C~Biotin_lipoyl, Biotin_carb_C~CPSase_L_D2, Biotin_carb_C~PYC_OADA, Biotin_carb_N~Biotin_carb_N, Biotin_carb_N~Biotin_lipoyl, Biotin_carb_N~CPSase_L_D2, Biotin_carb_N~PYC_OADA, Biotin_lipoyl~Biotin_lipoyl, Biotin_lipoyl~CPSase_L_D2, Biotin_lipoyl~PYC_OADA, CPSase_L_D2~CPSase_L_D2, HMGL-like~HMGL-like, HMGL-like~PYC_OADA, PYC_OADA~PYC_OADA
Common GO terms GO:0004736 - pyruvate carboxylase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
and 12 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 1178
Hs

1 1178
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+ Dm
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+ Sc
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Last updated: 15 Jul 2024