HitPredict

Interactor 1: MPRI (P11717)
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Gene: IGF2R

Interactor 2: GGA2 (Q9UJY4)
ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
Gene: GGA2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	0.60	0.739

Property	Details
Experiments	29358589, 31076515, 11387476, 14567678, 11390366, 11859375, 11387475
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005794 - Golgi apparatus GO:0005802 - trans-Golgi network GO:0010008 - endosome membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2491 Hs			1 613
+	Hs
		514929 MPRI_HUMAN (1-2491): 0: 4161: 100.00		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Mm
		612131 MPRI_MOUSE (7-2491): 0: 4155: 81.31		AP1G1_MOUSE (44-610): 6.95e-109: 347: 17.61
+	Bt
		59972 MPRI_BOVIN (1-2491): 0: 4005: 80.50		A4FUZ8_BOVIN (21-565): 4.04e-119: 367: 35.18
+	Bt
		436870 MPRI_BOVIN (1-2491): 0: 4005: 80.50		Q58CQ6_BOVIN (19-454): 2.01e-117: 358: 43.25
+	Bt
		102288 MPRI_BOVIN (1-2491): 0: 4005: 80.50		G3MZH4_BOVIN (44-610): 1.54e-104: 335: 17.57
+	Hs
		514920 MPRI_HUMAN (1-2491): 0: 4161: 100.00		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33
+	Dm
		81395 B7Z0Q8_DROME (917-1647): 2.46e-35: 149: 22.54		Q9W329_DROME (23-594): 2.99e-84: 278: 21.04