Protein: DBF2
Cell cycle protein kinase DBF2 (EC 2.7.11.1) (Dumbbell forming protein 2)

Gene: DBF2
Organism: Saccharomyces cerevisiae S288C
Interactions: 188
UniProt ID: P22204

Gene Ontology (top 5):
GO:0000280 - nuclear division
GO:0003723 - RNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645889

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

3

7

Small-scale

0.884

High

645966

CDC14
Tyrosine-protein phosphatase CDC14

3

10

Small-scale

0.857

High

645883

CDC15
Cell division control protein 15

2

20

Small-scale

0.806

High

645877

CG23
G2/mitotic-specific cyclin-3

2

7

Small-scale

0.789

High

645907

KKQ8
Probable serine/threonine-protein kinase KKQ8

2

17

Small-scale

0.778

High

645960

FPK1
Flippase kinase 1

2

18

Small-scale

0.778

High

645978

RRP5
rRNA biogenesis protein RRP5

2

5

Small-scale

0.778

High

645990

YP150
Putative serine/threonine-protein kinase YPL150W

2

9

Small-scale

0.778

High

645997

OSH2
Oxysterol-binding protein homolog 2

2

2

Small-scale

0.778

High

645936

MOB1
DBF2 kinase activator protein MOB1

12

20

Small-scale

0.763

High

645926

SSN3
Meiotic mRNA stability protein kinase SSN3

1

18

Small-scale

0.740

High

364333

CDK1
Cyclin-dependent kinase 1

1

11

High-throughput

0.724

High

448642

SNF1
Carbon catabolite-derepressing protein kinase

1

7

High-throughput

0.691

High

475108

CYAA
Adenylate cyclase

1

10

High-throughput

0.691

High

554664

YPK1
Serine/threonine-protein kinase YPK1

1

17

High-throughput

0.691

High

645878

SIS1
Protein SIS1

1

7

High-throughput

0.647

High

645917

SRO77
Lethal(2) giant larvae protein homolog SRO77

1

2

High-throughput

0.647

High

392241

HSP82
ATP-dependent molecular chaperone HSP82

1

20

High-throughput

0.646

High

578862

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.646

High

645895

RPN2
26S proteasome regulatory subunit RPN2

1

3

High-throughput

0.646

High

645925

POP2
Poly(A) ribonuclease POP2

3

0

Small-scale

0.622

High

464552

PBS2
MAP kinase kinase PBS2

1

17

High-throughput

0.618

High

645872

DBF2
Cell cycle protein kinase DBF2

1

18

High-throughput

0.618

High

645876

CG22
G2/mitotic-specific cyclin-2

1

7

Small-scale

0.618

High

645893

HOG1
Mitogen-activated protein kinase HOG1

1

11

High-throughput

0.618

High

645924

TEM1
Protein TEM1

1

11

High-throughput

0.618

High

645968

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

13

High-throughput

0.618

High

450705

KAD2
Adenylate kinase

2

3

Small-scale

0.602

High

636534

PSA7
Probable proteasome subunit alpha type-7

2

1

Small-scale

0.602

High

645896

PAH1
Phosphatidic acid phosphohydrolase 1

2

2

Small-scale

0.602

High

645962

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

2

1

Small-scale

0.602

High

645947

SYEC
Glutamate--tRNA ligase, cytoplasmic

2

3

High-throughput

0.602

High

645999

RUVB2
RuvB-like protein 2

2

5

High-throughput

0.594

High

645915

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.589

High

486032

TBA1
Tubulin alpha-1 chain

2

8

High-throughput

0.584

High

645972

RNT1
Ribonuclease 3

2

0

Small-scale

0.577

High

645904

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.571

High

386567

TBB
Tubulin beta chain

2

10

High-throughput

0.565

High

645884

BUD14
Bud site selection protein 14

2

0

High-throughput

0.561

High

645891

NUD1
Protein NUD1

1

13

High-throughput

0.553

High

525939

HSP72
Heat shock protein SSA2

2

15

High-throughput

0.552

High

645932

SSB2
Ribosome-associated molecular chaperone SSB2

2

14

High-throughput

0.552

High

394242

EF1A
Elongation factor 1-alpha

2

4

Small-scale

0.550

High

645919

AIM3
Altered inheritance of mitochondria protein 3

2

11

Small-scale

0.550

High

645922

YB8A
Putative uncharacterized protein YBR285W

2

1

Small-scale

0.550

High

645934

VPS27
Vacuolar protein sorting-associated protein 27

2

5

Small-scale

0.550

High

645935

VHS2
Protein VHS2

2

1

Small-scale

0.550

High

645954

AVT4
Vacuolar amino acid transporter 4

2

1

Small-scale

0.550

High

645973

ADD37
Alpha1-proteinase inhibitor-degradation deficient protein 37

2

1

Small-scale

0.550

High

645981

NVJ2
Nucleus-vacuole junction protein 2

2

1

Small-scale

0.550

High

645994

HSP42
Heat shock protein 42

2

2

High-throughput

0.549

High

603408

VATA
V-type proton ATPase catalytic subunit A

1

13

High-throughput

0.536

High

645886

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

3

High-throughput

0.536

High

645887

XPO1
Exportin-1

1

10

High-throughput

0.536

High

645890

PROB
Glutamate 5-kinase

1

2

High-throughput

0.536

High

645901

PRS6A
26S proteasome regulatory subunit 6A

1

10

High-throughput

0.536

High

645902

PRS6B
26S proteasome regulatory subunit 6B homolog

1

8

High-throughput

0.536

High

645939

SA185
SIT4-associating protein SAP185

1

2

High-throughput

0.536

High

645956

PNC1
Nicotinamidase

1

1

High-throughput

0.536

High

645977

EMI2
Putative glucokinase-2

1

3

High-throughput

0.536

High

464311

OAT
Ornithine aminotransferase

1

0

High-throughput

0.513

High

645953

RIB4
6,7-dimethyl-8-ribityllumazine synthase

1

0

High-throughput

0.513

High

645961

CAF40
Protein CAF40

1

1

Small-scale

0.508

High

645911

CAF4
CCR4-associated factor 4

1

17

Small-scale

0.504

High

368868

SYMC
Methionine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.501

High

381877

H4
Histone H4

1

3

Small-scale

0.501

High

514928

YA11A
Transposon Ty1-A Gag polyprotein

1

3

High-throughput

0.501

High

514990

YE11A
Transposon Ty1-ER1 Gag polyprotein

1

3

High-throughput

0.501

High

600650

SEC2
Rab guanine nucleotide exchange factor SEC2

1

1

High-throughput

0.501

High

601993

CBF1
Centromere-binding protein 1

1

2

Small-scale

0.501

High

645875

SSD1
Protein SSD1

1

3

High-throughput

0.501

High

645900

DRS1
ATP-dependent RNA helicase DRS1

1

12

High-throughput

0.501

High

645918

NCL1
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase

1

3

High-throughput

0.501

High

645931

BUD16
Putative pyridoxal kinase BUD16

1

2

High-throughput

0.501

High

645943

ELP2
Elongator complex protein 2

1

10

High-throughput

0.501

High

645958

H1
Histone H1

1

1

Small-scale

0.501

High

645970

MTD1
Methylenetetrahydrofolate dehydrogenase [NAD(+)]

1

1

High-throughput

0.501

High

645974

NHP10
Non-histone protein 10

1

10

High-throughput

0.501

High

645979

CYK2
Cytokinesis protein 2

1

2

Small-scale

0.501

High

645982

BDF2
Bromodomain-containing factor 2

1

8

High-throughput

0.501

High

645988

SAS10
Something about silencing protein 10

1

2

High-throughput

0.501

High

645995

NDJ1
Non-disjunction protein 1

1

1

High-throughput

0.501

High

645996

YN11A
Transposon Ty1-NL1 Gag polyprotein

1

3

High-throughput

0.501

High

646000

YG12A
Transposon Ty1-GR2 Gag polyprotein

1

3

High-throughput

0.501

High

646001

H2AZ
Histone H2A.Z

1

12

Small-scale

0.501

High

366931

ATPB
ATP synthase subunit beta, mitochondrial

1

10

High-throughput

0.500

High

416371

HXKA
Hexokinase-1

1

3

High-throughput

0.500

High

452817

ATPA
ATP synthase subunit alpha, mitochondrial

1

11

High-throughput

0.500

High

453423

PYR1
Multifunctional protein URA2

1

6

High-throughput

0.500

High

470462

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.500

High

481484

HSP73
Heat shock protein SSA3

1

15

High-throughput

0.500

High

531246

METK1
S-adenosylmethionine synthase 1

1

3

High-throughput

0.500

High

590533

HSP26
Heat shock protein 26

1

2

High-throughput

0.500

High

598953

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

9

High-throughput

0.500

High

645985

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

2

High-throughput

0.500

High

368321

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

7

High-throughput

0.489

High

446206

PHSG
Glycogen phosphorylase

1

4

High-throughput

0.489

High

575382

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

2

High-throughput

0.489

High

582411

SEC23
Protein transport protein SEC23

1

2

High-throughput

0.489

High

645913

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

High-throughput

0.489

High

645938

MKT1
Post-transcriptional regulator MKT1

1

1

High-throughput

0.489

High

645941

COPB2
Coatomer subunit beta'

1

7

High-throughput

0.489

High

645992

RPN5
26S proteasome regulatory subunit RPN5

1

1

High-throughput

0.489

High

645993

IQG1
Ras GTPase-activating-like protein IQG1

1

11

High-throughput

0.481

High

571026

CHS2
Chitin synthase 2

1

0

Small-scale

0.480

High

645910

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.480

High

645912

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.480

High

645923

RGD3
Rho-GTPase-activating protein RGD3

1

0

High-throughput

0.480

High

645929

OAF1
Oleate-activated transcription factor 1

1

0

Small-scale

0.480

High

645959

TR112
Multifunctional methyltransferase subunit TRM112

1

0

High-throughput

0.480

High

645984

NSE1
Non-structural maintenance of chromosomes element 1

1

0

High-throughput

0.480

High

453896

IF4E
Eukaryotic translation initiation factor 4E

1

2

High-throughput

0.479

High

645874

SPA2
Protein SPA2

1

11

High-throughput

0.479

High

645882

AP2B
AP-2 complex subunit beta

1

5

High-throughput

0.479

High

645885

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

645903

SEC3
Exocyst complex component SEC3

1

20

High-throughput

0.479

High

645906

SKI2
Antiviral helicase SKI2

1

12

High-throughput

0.479

High

645942

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

1

High-throughput

0.479

High

645945

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

4

High-throughput

0.479

High

645964

H3
Histone H3

1

9

High-throughput

0.479

High

645989

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

645991

RIO1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

438123

NOT2
General negative regulator of transcription subunit 2

1

0

Small-scale

0.460

High

645955

TAN1
tRNA acetyltransferase TAN1

1

0

High-throughput

0.458

High

645957

YG1T
Uncharacterized protein YGR042W

1

0

High-throughput

0.458

High

511372

RL43B
Large ribosomal subunit protein eL43B

1

1

High-throughput

0.457

High

582222

AMPD
AMP deaminase

1

2

High-throughput

0.457

High

645880

ADH7
NADP-dependent alcohol dehydrogenase 7

1

1

High-throughput

0.457

High

645888

RM09
Large ribosomal subunit protein uL3m

1

3

High-throughput

0.457

High

645908

AVT3
Vacuolar amino acid transporter 3

1

1

High-throughput

0.457

High

645921

MCFS2
Medium-chain fatty acid ethyl ester synthase/esterase 2

1

2

High-throughput

0.457

High

645948

ARC1
tRNA-aminoacylation cofactor ARC1

1

1

High-throughput

0.457

High

645951

YJ9J
Uncharacterized protein YJR142W

1

1

High-throughput

0.457

High

645952

HSV2
SVP1-like protein 2

1

8

High-throughput

0.457

High

645963

ESBP6
Uncharacterized transporter ESBP6

1

4

High-throughput

0.457

High

645975

YMD7
Uncharacterized protein YML037C

1

1

High-throughput

0.457

High

645980

BFR2
Protein BFR2

1

1

High-throughput

0.457

High

368592

PMG1
Phosphoglycerate mutase 1

1

6

High-throughput

0.457

High

425106

OTC
Ornithine carbamoyltransferase

1

6

High-throughput

0.457

High

450521

FAS1
Fatty acid synthase subunit beta

1

2

High-throughput

0.457

High

554880

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.457

High

619326

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.457

High

644712

CLH
Clathrin heavy chain

1

4

High-throughput

0.457

High

364931

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.445

High

510202

HSP77
Import motor subunit, mitochondrial

1

15

High-throughput

0.445

High

523078

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

543835

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

592016

VATB
V-type proton ATPase subunit B

1

11

High-throughput

0.445

High

645897

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

645898

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

645916

ADH5
Alcohol dehydrogenase 5

1

1

High-throughput

0.445

High

645927

TCPB
T-complex protein 1 subunit beta

1

11

High-throughput

0.445

High

645965

GPD1
Glycerol-3-phosphate dehydrogenase [NAD(+)] 1

1

1

High-throughput

0.445

High

645879

BPH1
Beige protein homolog 1

1

8

High-throughput

0.437

High

645892

HXT1
Low-affinity glucose transporter HXT1

1

1

High-throughput

0.437

High

645894

NUP2
Nucleoporin NUP2

1

7

High-throughput

0.437

High

645928

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

645937

AIM21
Altered inheritance of mitochondria protein 21

1

9

High-throughput

0.437

High

645969

MAP1
Methionine aminopeptidase 1

1

3

High-throughput

0.437

High

645971

UTP6
U3 small nucleolar RNA-associated protein 6

1

2

High-throughput

0.437

High

645986

AP3D
AP-3 complex subunit delta

1

6

High-throughput

0.437

High

645998

SPSY
Spermine synthase SPE4

1

1

High-throughput

0.437

High

645930

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

12

High-throughput

0.407

High

645949

NET1
Nucleolar protein NET1

4

0

Small-scale

0.361

High

645899

CDC13
Cell division control protein 13

2

0

Small-scale

0.314

High

645920

YBY8
Uncharacterized protein YBR138C

2

0

Small-scale

0.314

High

645944

PRM10
Pheromone-regulated membrane protein 10

2

0

Small-scale

0.314

High

542715

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.279

Low

558587

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.279

Low

645881

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.279

Low

645914

GLY1
Low specificity L-threonine aldolase

1

0

High-throughput

0.279

Low

645950

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.279

Low

645967

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.279

Low

357755

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.261

Low

438801

CYSD
Homocysteine/cysteine synthase

1

0

High-throughput

0.261

Low

645873

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.261

Low

645905

TGL1
Sterol esterase TGL1

1

0

High-throughput

0.261

Low

645909

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.261

Low

645940

YJV3
Uncharacterized protein YJL213W

1

0

High-throughput

0.261

Low

645976

YM54
Uncharacterized protein YMR196W

1

0

High-throughput

0.261

Low

645987

MCP1
Mitochondrial adapter protein MCP1

1

0

High-throughput

0.261

Low

432289

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.261

Low

484723

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

555006

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.261

Low

645946

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low

645933

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.249

Low

645983

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025