HitPredict

Interactor 1: KCC2A (P11798)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: Camk2a

Interactor 2: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28706196
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Pkinase~Ras
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0030425 - dendrite GO:0046427 - positive regulation of receptor signaling pathway via JAK-STAT GO:0046872 - metal ion binding and 1 others more... GO:0098978 - glutamatergic synapse
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 478 Mm			1 1186
+	Rn
		506765 KCC2A_RAT (1-478): 0: 569: 100.00		AGAP2_RAT (1-1186): 0: 1019: 99.07
+	Mm
		1112593 KCC2D_MOUSE (2-475): 0: 552: 87.55		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1112637 KCC2G_MOUSE (1-475): 0: 525: 76.43		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		659450 KCC2B_MOUSE (1-475): 1.19e-178: 513: 71.06		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Hs
		1357913 KCC2A_HUMAN (1-478): 0: 569: 99.79		GIT1_HUMAN (932-1139): 4.84e-72: 258: 32.88
+	Rn
		506783 KCC2A_RAT (1-478): 0: 569: 100.00		GIT1_RAT (932-1139): 1.69e-71: 257: 32.88
+	Hs
		1050113 KCC4_HUMAN (9-303): 2.31e-73: 240: 43.10		GIT2_HUMAN (932-1139): 1.58e-73: 262: 31.98
+	Hs
		1083229 KCC4_HUMAN (9-303): 2.31e-73: 240: 43.10		GIT1_HUMAN (932-1139): 4.84e-72: 258: 32.88