HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	8259215, 8101826, 33961781, 11254741
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 261
+	Bt
		1114085 CDK2_BOVIN (3-301): 7.81e-145: 410: 43.89		PCNA_BOVIN (1-261): 4.42e-126: 360: 99.23
+	Hs
		517061 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Mm
		572245 CDK2_MOUSE (3-301): 1.03e-135: 389: 37.89		PCNA_MOUSE (1-261): 1.25e-125: 358: 96.94
+	Hs
		414703 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Hs
		517198 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00
+	Bt
		1103882 CDK4_BOVIN (1-299): 1.2e-126: 365: 97.66		PCNA_BOVIN (1-261): 4.42e-126: 360: 99.23
+	Mm
		572238 CDK4_MOUSE (1-299): 5.01e-126: 363: 95.65		PCNA_MOUSE (1-261): 1.25e-125: 358: 96.94
+	Bt
		970690 CDK5_BOVIN (3-301): 6.95e-124: 357: 43.09		PCNA_BOVIN (1-261): 4.42e-126: 360: 99.23
+	Hs
		517199 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00