HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: FGFR4 (P22455)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (CD antigen CD334)
Gene: FGFR4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	I-set~Pkinase, PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 802
+	Hs
		609180 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		FGFR3_HUMAN (5-799): 0: 712: 61.07
+	Hs
		414737 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		FGFR4_HUMAN (13-802): 0: 750: 100.00
+	Hs
		507863 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		607942 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		FGFR4_HUMAN (13-802): 0: 750: 100.00
+	Hs
		414738 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		FGFR3_HUMAN (5-799): 0: 712: 61.07
+	Hs
		414702 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		FGFR1_HUMAN (3-794): 0: 706: 54.76
+	Hs
		515342 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		665211 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		EPHA2_HUMAN (4-789): 0: 573: 19.58
+	Hs
		384287 CDK2_HUMAN (3-301): 5.33e-145: 411: 44.22		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		414934 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		NTRK3_HUMAN (159-751): 2.33e-165: 501: 25.24
+	Hs
		384094 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Hs
		384174 CDK4_HUMAN (1-303): 2.42e-128: 369: 100.00		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Mm
		546285 CDK5_MOUSE (3-301): 6.95e-124: 357: 43.09		NTRK2_MOUSE (122-757): 5e-166: 503: 26.62
+	Hs
		384654 CDK6_HUMAN (5-300): 4.03e-127: 367: 70.03		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Rn
		974744 CDK5_RAT (3-301): 2.58e-123: 356: 43.42		NTRK2_RAT (122-757): 1.27e-165: 501: 26.62
+	Rn
		728443 CDK5_RAT (3-301): 2.58e-123: 356: 43.42		NTRK1_RAT (122-757): 3.86e-164: 497: 25.72
+	Hs
		384655 CDK5_HUMAN (3-301): 5.52e-124: 357: 43.09		NTRK1_HUMAN (135-751): 4.91e-162: 491: 26.53
+	Rn
		974740 CDK5_RAT (3-301): 2.58e-123: 356: 43.42		NTRK3_RAT (159-751): 6.79e-160: 488: 24.28
+	Hs
		414788 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		VGFR3_HUMAN (153-356): 9.15e-11: 67.8: 18.78
+	Hs
		414724 CDK1_HUMAN (3-300): 8.98e-130: 372: 42.24		VGFR1_HUMAN (26-128): 1.78e-10: 67: 22.22