HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CCND2 (P30279)
G1/S-specific cyclin-D2
Gene: CCND2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 25910212, 17873913, 30217970, 27107012, 11971966, 28205554, 11360184, 15169570, 26186194, 28514442, 10022865, 32296183, 33961781, 9178893, 9325318, unassigned1304, 31515488, 11896535
Identification Methods two hybrid, affinity chromatography technology, fluorescent resonance energy transfer, coimmunoprecipitation, barcode fusion genetics two hybrid, validated two hybrid, split luciferase complementation, two hybrid bait and prey pooling approach, two hybrid array, two hybrid prey pooling approach and 2 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 8 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 303
Hs

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Last updated: 15 Jul 2024