HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: CCND3 (P30281)
G1/S-specific cyclin-D3
Gene: CCND3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.993

The method score is based on:

Property Details
Experiments 21516116, 26496610, 25910212, 30217970, 27107012, 11360184, 10342870, 33961781, 16985050, 23880157, 25416956, 26186194, 16189514, 28514442, 14641107, 32296183, 33854235, 23737759, 34591612, 9716181 and 8 others

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Identification Methods two hybrid, affinity chromatography technology, pull down, molecular sieving, light scattering, x-ray crystallography, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, barcode fusion genetics two hybrid and 6 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 6 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 303
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024