HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: IF4A1 (P60842)
Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1)
Gene: EIF4A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	9548260, 29395067, 35271311, 20133758
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 406
+	Hs
		516515 PABP1_HUMAN (1-636): 0: 582: 100.00		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		1031325 PABP4_HUMAN (1-635): 0: 534: 74.69		IF4A2_HUMAN (4-406): 4.47e-158: 453: 90.32
+	Hs
		516391 PABP1_HUMAN (1-636): 0: 582: 100.00		IF4A3_HUMAN (1-406): 1.93e-134: 393: 66.75
+	Hs
		892791 PABP4_HUMAN (1-635): 0: 534: 74.69		IF4A1_HUMAN (1-406): 1.84e-132: 387: 100.00
+	Hs
		516363 PABP1_HUMAN (1-636): 0: 582: 100.00		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		640620 PABP3_HUMAN (1-636): 0: 541: 91.37		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Hs
		640464 PABP4_HUMAN (1-635): 0: 534: 74.69		DDX6_HUMAN (32-402): 1.66e-88: 278: 38.71
+	Mm
		857323 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		DDX17_MOUSE (2-406): 1.38e-137: 409: 29.33
+	Mm
		857351 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		Q8BTS0_MOUSE (10-406): 4.82e-138: 409: 29.88
+	Sc
		376792 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		DHH1_YEAST (32-402): 1.41e-99: 307: 44.47
+	Mm
		857295 TIA1_MOUSE (4-172): 1.01e-34: 137: 27.51		IF4A1_MOUSE (1-406): 1.84e-132: 387: 100.00
+	Hs
		571302 NUCL_HUMAN (3-89): 2.56e-19: 94.1: 33.33		DDX5_HUMAN (10-406): 3.38e-138: 409: 29.88