HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: PMS2 (P54278)
Mismatch repair endonuclease PMS2 (EC 3.1.-.-) (DNA mismatch repair protein PMS2) (PMS1 protein homolog 2)
Gene: PMS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	28439008, 17148452, 15225546
Identification Methods	pull down, affinity chromatography technology, far western blotting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006298 - mismatch repair
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 862
+	Sc
		536211 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		PMS1_YEAST (14-856): 0: 695: 34.25
+	Hs
		517112 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		MLH1_HUMAN (12-505): 3.98e-151: 464: 25.61
+	Sc
		550545 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		MLH1_YEAST (15-597): 4.38e-142: 441: 22.43
+	Hs
		517526 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		MLH3_HUMAN (668-861): 2.26e-45: 179: 20.17
+	Sc
		550582 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		MLH3_YEAST (518-856): 1.19e-66: 238: 18.46