HitPredict

Interactor 1: PCNA (P12004)
Proliferating cell nuclear antigen (PCNA) (Cyclin)
Gene: PCNA

Interactor 2: EXO1 (Q9UQ84)
Exonuclease 1 (hExo1) (EC 3.1.-.-) (Exonuclease I) (hExoI)
Gene: EXO1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.840

Property	Details
Experiments	20970388, 25833945, 15225546
Identification Methods	pull down, affinity chromatography technology, far western blotting
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PCNA_C~XPG_I, PCNA_C~XPG_N, PCNA_N~XPG_N
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006298 - mismatch repair GO:0016604 - nuclear body
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 261 Hs			1 846
+	Hs
		517111 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		FEN1_HUMAN (1-365): 6e-128: 390: 25.93
+	Dm
		572183 PCNA_DROME (1-259): 1.18e-122: 351: 71.04		FEN1_DROME (1-359): 3.8e-118: 365: 25.47
+	Sc
		550523 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		FEN1_YEAST (1-366): 7.09e-116: 359: 22.96
+	Hs
		517072 PCNA_HUMAN (1-261): 1.04e-125: 359: 100.00		ERCC5_HUMAN (1-97): 3.18e-30: 131: 25.77
+	Sc
		550549 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		YEN1_YEAST (1-282): 1.43e-46: 180: 16.38
+	Sc
		425538 PCNA_YEAST (1-259): 1.46e-99: 293: 35.52		RAD2_YEAST (1-109): 4.28e-32: 136: 25.69