HitPredict

Interactor 1: NFH (P12036)
Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein)
Gene: NEFH

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.50	0.407

Property	Details
Experiments	21182203
Identification Methods	cosedimentation through density gradient
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1020 Hs			1 530
+	Hs
		318855 K2C75_HUMAN (3-416): 1.44e-84: 285: 27.58		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1062061 K2C72_HUMAN (22-416): 2.25e-79: 270: 26.54		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		280820 KRT36_HUMAN (17-458): 1.09e-74: 256: 25.39		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		213976 KRT86_HUMAN (6-413): 3.33e-70: 244: 26.41		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369795 K2C79_HUMAN (13-416): 1.55e-85: 287: 26.65		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		943688 KRT85_HUMAN (5-413): 4.71e-68: 238: 26.28		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		443700 VIME_HUMAN (93-437): 6.65e-63: 223: 46.99		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370133 KRT35_HUMAN (4-450): 5.33e-72: 248: 25.45		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		535502 GFAP_HUMAN (93-413): 6.41e-53: 193: 46.73		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		781951 PERI_HUMAN (91-480): 1.6e-45: 172: 39.74		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368816 K2C8_HUMAN (92-416): 6.15e-39: 154: 34.15		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		422361 NFM_HUMAN (96-773): 4.72e-65: 239: 41.73		NR4A2_HUMAN (23-501): 3.24e-98: 311: 23.30
+	Mm
		509286 VIME_MOUSE (93-475): 3.06e-63: 224: 43.23		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		443425 VIME_HUMAN (93-437): 6.65e-63: 223: 46.99		NR1H2_HUMAN (49-499): 2.78e-103: 319: 20.86
+	Hs
		443331 VIME_HUMAN (93-437): 6.65e-63: 223: 46.99		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Mm
		509290 DESM_MOUSE (91-470): 3.43e-56: 204: 42.52		RARA_MOUSE (52-508): 5.87e-105: 324: 23.58
+	Hs
		320165 GFAP_HUMAN (93-413): 6.41e-53: 193: 46.73		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		487082 K2C3_HUMAN (70-414): 6.83e-111: 359: 29.71		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		422132 NFL_HUMAN (97-511): 4.23e-46: 176: 40.96		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		408982 K2C8_HUMAN (92-416): 6.15e-39: 154: 34.15		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59