Protein: GAB1
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)

Gene: GAB1
Organism: Homo sapiens
Interactions: 165
UniProt ID: Q13480

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005911 - cell-cell junction
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

924547

GRB2
Growth factor receptor-bound protein 2

19

20

Small-scale

0.990

High

338380

EGFR
Epidermal growth factor receptor

12

20

Small-scale

0.977

High

275195

GRAP2
GRB2-related adapter protein 2

7

20

Small-scale

0.963

High

802837

CRKL
Crk-like protein

4

20

Small-scale

0.886

High

581001

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

3

7

Small-scale

0.870

High

441499

MET
Hepatocyte growth factor receptor

3

20

Small-scale

0.827

High

411709

LCK
Tyrosine-protein kinase Lck

2

20

High-throughput

0.789

High

433750

LYN
Tyrosine-protein kinase Lyn

2

20

High-throughput

0.789

High

802588

CRK
Adapter molecule crk

2

20

High-throughput

0.789

High

596400

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.777

High

985952

PTN11
Tyrosine-protein phosphatase non-receptor type 11

17

15

Small-scale

0.765

High

655356

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

11

20

Small-scale

0.760

High

350144

RASK
GTPase KRas

2

20

High-throughput

0.754

High

384791

NTRK1
High affinity nerve growth factor receptor

2

20

High-throughput

0.754

High

507983

FGFR1
Fibroblast growth factor receptor 1

2

20

Small-scale

0.754

High

434188

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

Small-scale

0.737

High

1035386

MARK2
Serine/threonine-protein kinase MARK2

1

1

Small-scale

0.724

High

1035399

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

6

Small-scale

0.724

High

981867

RON
Macrophage-stimulating protein receptor

1

20

Small-scale

0.713

High

209049

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.692

High

426958

FES
Tyrosine-protein kinase Fes/Fps

1

20

High-throughput

0.692

High

433345

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.692

High

442825

HCK
Tyrosine-protein kinase HCK

1

20

High-throughput

0.692

High

522965

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.692

High

548703

VAV
Proto-oncogene vav

1

19

High-throughput

0.692

High

557681

NCK1
SH2/SH3 adapter protein NCK1

1

20

High-throughput

0.692

High

562645

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

4

High-throughput

0.692

High

788991

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.692

High

796565

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.692

High

846468

BLK
Tyrosine-protein kinase Blk

1

20

High-throughput

0.692

High

855792

VAV2
Guanine nucleotide exchange factor VAV2

1

17

High-throughput

0.692

High

986372

BTK
Tyrosine-protein kinase BTK

1

20

High-throughput

0.692

High

996561

ITK
Tyrosine-protein kinase ITK/TSK

1

20

High-throughput

0.692

High

1028466

SLAP1
Src-like-adapter

1

20

High-throughput

0.692

High

1035373

PTK6
Protein-tyrosine kinase 6

1

20

High-throughput

0.692

High

1035406

SLAP2
Src-like-adapter 2

1

20

High-throughput

0.692

High

1035409

TENS1
Tensin-1

1

7

High-throughput

0.692

High

1035413

VAV3
Guanine nucleotide exchange factor VAV3

1

20

High-throughput

0.692

High

881505

ARL4C
ADP-ribosylation factor-like protein 4C

1

9

High-throughput

0.691

High

666100

SHC1
SHC-transforming protein 1

3

20

Small-scale

0.674

High

64703

RHG32
Rho GTPase-activating protein 32

1

12

Small-scale

0.665

High

1035414

STAP1
Signal-transducing adaptor protein 1

1

0

High-throughput

0.657

High

383784

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.647

High

616804

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.647

High

681831

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.647

High

674415

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.646

High

667460

CASP1
Caspase-1

3

0

High-throughput

0.638

High

974802

CAV1
Caveolin-1

3

3

High-throughput

0.633

High

827368

EFTU
Elongation factor Tu, mitochondrial

2

2

High-throughput

0.628

High

1035417

GAB2
GRB2-associated-binding protein 2

1

13

Small-scale

0.621

High

120421

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.618

High

348648

RASN
GTPase NRas

1

20

High-throughput

0.618

High

349293

RASH
GTPase HRas

1

20

High-throughput

0.618

High

435634

IGF1R
Insulin-like growth factor 1 receptor

1

20

High-throughput

0.618

High

452414

PGFRB
Platelet-derived growth factor receptor beta

1

13

High-throughput

0.618

High

564515

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

665596

EPHB2
Ephrin type-B receptor 2

1

20

High-throughput

0.618

High

666592

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.618

High

784000

KPCI
Protein kinase C iota type

1

5

Small-scale

0.618

High

835358

GSK3A
Glycogen synthase kinase-3 alpha

1

7

High-throughput

0.618

High

835727

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.618

High

872642

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.618

High

876375

AFAD
Afadin

1

18

High-throughput

0.618

High

892354

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

900445

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

914051

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.618

High

915656

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

925254

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

950975

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.618

High

1035371

GAB1
GRB2-associated-binding protein 1

1

13

High-throughput

0.618

High

1035374

RAB35
Ras-related protein Rab-35

1

9

High-throughput

0.618

High

1035376

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.618

High

1035379

AR13B
ADP-ribosylation factor-like protein 13B

1

6

High-throughput

0.618

High

1035387

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1035392

FRS2
Fibroblast growth factor receptor substrate 2

1

2

Small-scale

0.618

High

1035405

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1035408

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.618

High

1035415

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

814942

LEG7
Galectin-7

2

1

High-throughput

0.611

High

927011

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1020092

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

2

9

Small-scale

0.595

High

547038

EZRI
Ezrin

2

16

High-throughput

0.584

High

577020

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

2

8

High-throughput

0.584

High

1035391

PARD3
Partitioning defective 3 homolog

2

20

Small-scale

0.584

High

1035167

ROCK1
Rho-associated protein kinase 1

1

6

Small-scale

0.575

High

516497

PABP1
Polyadenylate-binding protein 1

2

3

High-throughput

0.571

High

542307

PLAK
Junction plakoglobin

2

9

High-throughput

0.571

High

551692

DESP
Desmoplakin

2

11

High-throughput

0.571

High

923978

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

4

High-throughput

0.571

High

970767

DSG1
Desmoglein-1

2

9

High-throughput

0.571

High

1035403

PABP3
Polyadenylate-binding protein 3

2

3

High-throughput

0.571

High

1035412

CALL5
Calmodulin-like protein 5

2

3

High-throughput

0.571

High

318127

DIRA3
GTP-binding protein Di-Ras3

1

7

High-throughput

0.553

High

607961

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.553

High

665234

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.553

High

872436

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.553

High

1035375

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.553

High

1035383

STYK1
Tyrosine-protein kinase STYK1

1

20

High-throughput

0.553

High

1035416

TF2AY
TFIIA-alpha and beta-like factor

1

0

High-throughput

0.549

High

129290

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.536

High

147419

SOCS3
Suppressor of cytokine signaling 3

1

20

High-throughput

0.536

High

147519

SOCS6
Suppressor of cytokine signaling 6

1

20

High-throughput

0.536

High

155842

SH21B
SH2 domain-containing protein 1B

1

20

High-throughput

0.536

High

176441

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

4

High-throughput

0.536

High

275569

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

20

High-throughput

0.536

High

1035381

TENS3
Tensin-3

1

6

High-throughput

0.536

High

1035389

TENS4
Tensin-4

1

11

High-throughput

0.536

High

1035393

BLNK
B-cell linker protein

1

17

High-throughput

0.536

High

1035394

SHC3
SHC-transforming protein 3

1

20

High-throughput

0.536

High

1035395

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

High-throughput

0.536

High

1035397

HSH2D
Hematopoietic SH2 domain-containing protein

1

20

High-throughput

0.536

High

1035411

SH22A
SH2 domain-containing protein 2A

1

20

High-throughput

0.536

High

823387

PAXI
Paxillin

1

4

Small-scale

0.536

High

1035388

CUL9
Cullin-9

1

1

High-throughput

0.536

High

789775

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

1

High-throughput

0.521

High

1035402

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

2

8

High-throughput

0.521

High

1029222

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1035418

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

616917

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

6

High-throughput

0.501

High

796400

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

9

High-throughput

0.501

High

808579

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.501

High

983481

PTN12
Tyrosine-protein phosphatase non-receptor type 12

1

17

High-throughput

0.501

High

1035400

SH23A
SH2 domain-containing protein 3A

1

20

High-throughput

0.489

High

1035401

TRI15
E3 ubiquitin-protein ligase TRIM15

1

2

Small-scale

0.481

High

212824

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

279541

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

324378

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

444726

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

9

Small-scale

0.479

High

567046

CXA1
Gap junction alpha-1 protein

1

7

High-throughput

0.479

High

646871

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

670013

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

683323

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

684018

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

793303

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.479

High

904528

1433G
14-3-3 protein gamma

1

20

High-throughput

0.479

High

909527

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

928592

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.479

High

940416

CXAR
Coxsackievirus and adenovirus receptor

1

8

High-throughput

0.479

High

981984

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

990045

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

Small-scale

0.479

High

1017622

STX4
Syntaxin-4

1

6

High-throughput

0.479

High

1035372

CUL4B
Cullin-4B

1

3

High-throughput

0.479

High

1035377

OCLN
Occludin

1

4

High-throughput

0.479

High

1035398

FMNL2
Formin-like protein 2

1

2

High-throughput

0.479

High

1035404

DNJC5
DnaJ homolog subfamily C member 5

1

7

High-throughput

0.479

High

1035407

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1035410

E41LA
Band 4.1-like protein 4A

1

12

High-throughput

0.479

High

966692

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

0

Small-scale

0.458

High

441197

PTPRC
Receptor-type tyrosine-protein phosphatase C

1

8

High-throughput

0.457

High

617108

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

6

High-throughput

0.457

High

1035378

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

5

High-throughput

0.457

High

787224

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

7

High-throughput

0.445

High

178520

STX7
Syntaxin-7

1

6

High-throughput

0.437

High

305443

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.437

High

521912

CADH1
Cadherin-1

1

6

High-throughput

0.437

High

1035382

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1035384

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1035390

CXD3
Gap junction delta-3 protein

1

7

High-throughput

0.437

High

1035396

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

822542

PK3CG
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

1

7

Small-scale

0.408

High

685207

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

2

Small-scale

0.373

High

1035380

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

2

0

High-throughput

0.298

High

1035385

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.279

Low

439118

SYPH
Synaptophysin

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024