HitPredict

Interactor 1: KAPC1 (P12370)
cAMP-dependent protein kinase catalytic subunit 1 (PKA C) (EC 2.7.11.11) (Protein kinase DC0)
Gene: Pka-C1

Interactor 2: KAPR2 (P81900)
cAMP-dependent protein kinase type II regulatory subunit
Gene: Pka-R2

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	25294943, 22036573, unassigned4
Identification Methods	affinity chromatography technology, experimental interaction detection, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~cNMP_binding
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005952 - cAMP-dependent protein kinase complex GO:0007622 - rhythmic behavior and 1 others more... GO:0071361 - cellular response to ethanol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 353 Dm			1 377
+	Hs
		533786 KAPCB_HUMAN (1-353): 5.59e-158: 448: 82.15		KAP2_HUMAN (9-376): 8.24e-119: 352: 46.75
+	Hs
		533780 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		KAP2_HUMAN (9-376): 8.24e-119: 352: 46.75
+	Hs
		533784 KAPCG_HUMAN (1-353): 1.47e-156: 444: 74.50		KAP2_HUMAN (9-376): 8.24e-119: 352: 46.75
+	Hs
		610686 KAPCB_HUMAN (1-353): 5.59e-158: 448: 82.15		KAP3_HUMAN (9-375): 1.13e-113: 339: 42.51
+	Hs
		568559 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		KAP3_HUMAN (9-375): 1.13e-113: 339: 42.51
+	Hs
		609647 KAPCG_HUMAN (1-353): 1.47e-156: 444: 74.50		KAP3_HUMAN (9-375): 1.13e-113: 339: 42.51
+	Mm
		397199 KAPCA_MOUSE (1-353): 1.93e-156: 444: 81.59		KAP3_MOUSE (9-375): 5.85e-113: 337: 42.72
+	Hs
		610685 KAPCB_HUMAN (1-353): 5.59e-158: 448: 82.15		KAP1_HUMAN (14-361): 7.75e-110: 328: 38.81
+	Hs
		568558 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		KAP1_HUMAN (14-361): 7.75e-110: 328: 38.81
+	Hs
		609646 KAPCG_HUMAN (1-353): 1.47e-156: 444: 74.50		KAP1_HUMAN (14-361): 7.75e-110: 328: 38.81
+	Mm
		397222 KAPCA_MOUSE (1-353): 1.93e-156: 444: 81.59		KAP0_MOUSE (15-361): 5.67e-107: 320: 38.35
+	Hs
		498210 KAPCB_HUMAN (1-353): 5.59e-158: 448: 82.15		KAP0_HUMAN (15-361): 3.88e-105: 316: 37.78
+	Hs
		498202 KAPCA_HUMAN (1-353): 7.35e-158: 447: 82.44		KAP0_HUMAN (15-361): 3.88e-105: 316: 37.78
+	Hs
		498208 KAPCG_HUMAN (1-353): 1.47e-156: 444: 74.50		KAP0_HUMAN (15-361): 3.88e-105: 316: 37.78
+	Hs
		498221 AKT1_HUMAN (20-349): 3.04e-147: 425: 38.81		KAP0_HUMAN (15-361): 3.88e-105: 316: 37.78
+	Ce
		596863 KAPC1_CAEEL (3-353): 6.42e-145: 417: 72.36		KAPR_CAEEL (15-366): 1.16e-97: 296: 37.01
+	Sc
		412617 KAPA_YEAST (2-353): 6.5e-146: 419: 43.61		KAPR_YEAST (25-358): 4.73e-86: 268: 38.62
+	Dm
		519451 KAPC1_DROME (1-353): 6.52e-161: 456: 100.00		KAPR1_DROME (214-370): 1.04e-19: 91.3: 24.84
+	Dm
		532273 KPC3_DROME (32-353): 3.92e-141: 419: 37.24		Q7K3Z6_DROME (216-371): 1.17e-29: 122: 24.22
+	Dm
		51594 KPC3_DROME (32-353): 3.92e-141: 419: 37.24		A1Z6P8_DROME (102-235): 4.34e-13: 72.8: 18.88