Protein: MYBB
Myb-related protein B (B-Myb) (Myb-like protein 2)

Gene: MYBB, MYBL2
Organism: Homo sapiens
Interactions: 150
UniProt ID: P10244

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

519519

LIN9
Protein lin-9 homolog

12

3

Small-scale

0.758

High

519537

HDAC2
Histone deacetylase 2

2

3

Small-scale

0.754

High

519538

CBP
CREB-binding protein

2

9

Small-scale

0.754

High

519547

LIN37
Protein lin-37 homolog

9

2

Small-scale

0.751

High

519492

RBBP4
Histone-binding protein RBBP4

8

7

Small-scale

0.751

High

519493

EP300
Histone acetyltransferase p300

1

13

Small-scale

0.724

High

519517

LIN52
Protein lin-52 homolog

5

2

Small-scale

0.716

High

519456

MYBB
Myb-related protein B

1

15

Small-scale

0.713

High

519520

LIN54
Protein lin-54 homolog

4

4

Small-scale

0.691

High

519465

RBL1
Retinoblastoma-like protein 1

3

4

Small-scale

0.664

High

519491

FOXM1
Forkhead box protein M1

3

3

Small-scale

0.656

High

519461

CDK2
Cyclin-dependent kinase 2

3

20

Small-scale

0.655

High

519481

CCNA1
Cyclin-A1

2

2

Small-scale

0.629

High

316731

MTA2
Metastasis-associated protein MTA2

1

5

High-throughput

0.618

High

352060

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.618

High

519504

MTA1
Metastasis-associated protein MTA1

1

5

High-throughput

0.618

High

519555

MTA3
Metastasis-associated protein MTA3

1

7

High-throughput

0.618

High

519571

MBD2
Methyl-CpG-binding domain protein 2

1

1

High-throughput

0.618

High

143387

E2F3
Transcription factor E2F3

2

6

Small-scale

0.586

High

371009

MYC
Myc proto-oncogene protein

2

12

High-throughput

0.584

High

519506

NFIX
Nuclear factor 1 X-type

2

8

High-throughput

0.584

High

519476

CDK9
Cyclin-dependent kinase 9

1

20

Small-scale

0.578

High

486882

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.561

High

519469

CCNF
Cyclin-F

1

5

Small-scale

0.561

High

519475

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

1

Small-scale

0.561

High

519542

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

Small-scale

0.549

High

519544

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

7

High-throughput

0.541

High

519559

TRI15
E3 ubiquitin-protein ligase TRIM15

1

2

High-throughput

0.541

High

519580

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

2

High-throughput

0.541

High

519472

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

519490

CTSL2
CTD small phosphatase-like protein 2

1

1

High-throughput

0.536

High

519515

ZSC26
Zinc finger and SCAN domain-containing protein 26

1

1

High-throughput

0.536

High

519557

NUF2
Kinetochore protein Nuf2

1

2

High-throughput

0.536

High

519457

H14
Histone H1.4

1

2

High-throughput

0.515

High

519458

H15
Histone H1.5

1

3

High-throughput

0.515

High

417228

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

519510

TEAD2
Transcriptional enhancer factor TEF-4

1

0

High-throughput

0.513

High

519541

P2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

1

0

High-throughput

0.513

High

519514

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.508

High

519561

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.508

High

519578

TTF2
Transcription termination factor 2

1

20

Small-scale

0.508

High

519460

CCNE1
G1/S-specific cyclin-E1

1

3

Small-scale

0.501

High

519471

PA24A
Cytosolic phospholipase A2

1

0

Small-scale

0.493

High

519502

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.493

High

519486

E2F1
Transcription factor E2F1

1

6

Small-scale

0.481

High

142797

NFIB
Nuclear factor 1 B-type

1

7

High-throughput

0.479

High

210236

PHF1
PHD finger protein 1

1

3

High-throughput

0.479

High

243518

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

15

High-throughput

0.479

High

274280

SIN3B
Paired amphipathic helix protein Sin3b

1

5

High-throughput

0.479

High

285048

EED
Polycomb protein EED

1

8

High-throughput

0.479

High

339638

KLF8
Krueppel-like factor 8

1

4

High-throughput

0.479

High

386428

SPTA1
Spectrin alpha chain, erythrocytic 1

1

9

Small-scale

0.479

High

403769

GCR
Glucocorticoid receptor

1

5

High-throughput

0.479

High

473746

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

482997

CLCA
Clathrin light chain A

1

1

Small-scale

0.479

High

519459

FLNA
Filamin-A

1

3

Small-scale

0.479

High

519462

PAX6
Paired box protein Pax-6

1

3

High-throughput

0.479

High

519463

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

519464

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

15

High-throughput

0.479

High

519466

COIL
Coilin

1

1

High-throughput

0.479

High

519467

IF4A3
Eukaryotic initiation factor 4A-III

1

7

High-throughput

0.479

High

519470

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

High-throughput

0.479

High

519473

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

519474

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.479

High

519477

PLK1
Serine/threonine-protein kinase PLK1

1

14

High-throughput

0.479

High

519479

H4
Histone H4

1

2

High-throughput

0.479

High

519480

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

519482

H33
Histone H3.3

1

4

High-throughput

0.479

High

519484

CLH1
Clathrin heavy chain 1

1

3

Small-scale

0.479

High

519485

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

7

Small-scale

0.479

High

519487

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

519488

IRF8
Interferon regulatory factor 8

1

2

High-throughput

0.479

High

519489

TLE3
Transducin-like enhancer protein 3

1

5

High-throughput

0.479

High

519494

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

3

High-throughput

0.479

High

519495

BPTF
Nucleosome-remodeling factor subunit BPTF

1

11

High-throughput

0.479

High

519496

CDC20
Cell division cycle protein 20 homolog

1

9

Small-scale

0.479

High

519497

NFIA
Nuclear factor 1 A-type

1

9

High-throughput

0.479

High

519498

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

10

High-throughput

0.479

High

519499

CAF1A
Chromatin assembly factor 1 subunit A

1

4

High-throughput

0.479

High

519500

CAF1B
Chromatin assembly factor 1 subunit B

1

5

High-throughput

0.479

High

519501

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.479

High

519503

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.479

High

519505

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

High-throughput

0.479

High

519507

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

20

High-throughput

0.479

High

519508

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

519509

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

519511

ELF2
ETS-related transcription factor Elf-2

1

6

High-throughput

0.479

High

519512

EZH2
Histone-lysine N-methyltransferase EZH2

1

9

High-throughput

0.479

High

519513

E2F4
Transcription factor E2F4

1

6

Small-scale

0.479

High

519516

ARI4B
AT-rich interactive domain-containing protein 4B

1

7

High-throughput

0.479

High

519518

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

1

High-throughput

0.479

High

519522

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

519523

P66A
Transcriptional repressor p66-alpha

1

2

High-throughput

0.479

High

519525

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

519526

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

519529

NUP43
Nucleoporin Nup43

1

12

High-throughput

0.479

High

519531

SP7
Transcription factor Sp7

1

3

High-throughput

0.479

High

519532

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

10

High-throughput

0.479

High

519533

ZN296
Zinc finger protein 296

1

2

High-throughput

0.479

High

519534

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

519535

P66B
Transcriptional repressor p66-beta

1

2

High-throughput

0.479

High

519536

CNOT9
CCR4-NOT transcription complex subunit 9

1

11

High-throughput

0.479

High

519539

SYMPK
Symplekin

1

1

High-throughput

0.479

High

519540

EZH1
Histone-lysine N-methyltransferase EZH1

1

9

High-throughput

0.479

High

519545

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

519549

PWP2A
PWWP domain-containing protein 2A

1

3

High-throughput

0.479

High

519550

PHF12
PHD finger protein 12

1

7

High-throughput

0.479

High

519551

SIN3A
Paired amphipathic helix protein Sin3a

1

5

High-throughput

0.479

High

519552

FEV
Protein FEV

1

5

High-throughput

0.479

High

519553

ELF4
ETS-related transcription factor Elf-4

1

6

High-throughput

0.479

High

519554

EPAS1
Endothelial PAS domain-containing protein 1

1

1

Small-scale

0.479

High

519556

KLF16
Krueppel-like factor 16

1

3

High-throughput

0.479

High

519560

BC11B
B-cell lymphoma/leukemia 11B

1

3

High-throughput

0.479

High

519562

SP130
Histone deacetylase complex subunit SAP130

1

3

High-throughput

0.479

High

519563

BC11A
BCL11 transcription factor A

1

4

High-throughput

0.479

High

519564

HIPK2
Homeodomain-interacting protein kinase 2

1

20

Small-scale

0.479

High

519566

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

1

High-throughput

0.479

High

519570

ZN219
Zinc finger protein 219

1

2

High-throughput

0.479

High

519572

NLK
Serine/threonine-protein kinase NLK

1

20

Small-scale

0.479

High

519574

ZMYM2
Zinc finger MYM-type protein 2

1

1

High-throughput

0.479

High

519576

KLF15
Krueppel-like factor 15

1

3

High-throughput

0.479

High

519581

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.479

High

155281

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.458

High

168181

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

282217

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.458

High

378468

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

413062

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

519483

NDP
Norrin

1

0

Small-scale

0.458

High

519521

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

519524

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.458

High

519528

HJURP
Holliday junction recognition protein

1

0

High-throughput

0.458

High

519548

Z512B
Zinc finger protein 512B

1

0

High-throughput

0.458

High

519558

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.458

High

519565

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

519569

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

519573

LHX3
LIM/homeobox protein Lhx3

1

0

High-throughput

0.458

High

519579

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

519543

VP33A
Vacuolar protein sorting-associated protein 33A

1

2

High-throughput

0.437

High

519575

HMGX4
HMG domain-containing protein 4

1

4

High-throughput

0.437

High

519577

PNMA2
Paraneoplastic antigen Ma2

2

0

High-throughput

0.313

High

519478

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.282

High

519527

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

0

High-throughput

0.282

High

417907

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.279

Low

505126

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

519468

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

519530

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

519567

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.249

Low

519568

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low

519546

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025