HitPredict

Interactor 1: ACTN1 (P12814)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Interactor 2: ZYX (Q15942)
Zyxin (Zyxin-2)
Gene: ZYX

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	10224105, 11423549
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001725 - stress fiber GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 892 Hs			1 572
+	Mm
		1186636 ACTN1_MOUSE (1-892): 0: 694: 99.22		PDLI5_MOUSE (29-568): 1.27e-60: 212: 16.61
+	Gg
		396532 ACTN1_CHICK (3-892): 0: 682: 97.75		ZYX_CHICK (2-572): 1.43e-63: 219: 41.70
+	Hs
		211588 ACTN4_HUMAN (11-892): 0: 642: 86.74		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		725659 ACTN2_HUMAN (10-892): 0: 640: 80.29		ZYX_HUMAN (1-572): 1.68e-71: 241: 100.00
+	Hs
		521634 ACTN1_HUMAN (1-892): 0: 697: 100.00		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		211685 ACTN4_HUMAN (11-892): 0: 642: 86.74		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28
+	Hs
		963447 SPTB2_HUMAN (196-761): 3.97e-14: 79.3: 12.17		TES_HUMAN (345-499): 3.83e-20: 95.1: 17.28