Protein: H1T
Histone H1t (Testicular H1 histone)

Gene: H1T, H1-6
Organism: Homo sapiens
Interactions: 249
UniProt ID: P22492

Gene Ontology (top 5):
GO:0000786 - nucleosome
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus
GO:0006334 - nucleosome assembly
GO:0007283 - spermatogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

521539

H14
Histone H1.4

4

16

High-throughput

0.895

High

649387

H2B1A
Histone H2B type 1-A

3

20

High-throughput

0.861

High

649295

H33
Histone H3.3

3

20

High-throughput

0.847

High

591476

H2AX
Histone H2AX

2

20

High-throughput

0.811

High

418832

H2A1B
Histone H2A type 1-B/E

2

20

High-throughput

0.789

High

502238

H2A1
Histone H2A type 1

2

20

High-throughput

0.789

High

595314

H15
Histone H1.5

2

16

High-throughput

0.789

High

595681

H13
Histone H1.3

2

16

High-throughput

0.789

High

649293

H31
Histone H3.1

2

20

High-throughput

0.789

High

649298

H11
Histone H1.1

2

15

High-throughput

0.789

High

595936

H12
Histone H1.2

2

16

High-throughput

0.754

High

649281

H2B1C
Histone H2B type 1-C/E/F/G/I

2

20

High-throughput

0.754

High

649325

H2A2C
Histone H2A type 2-C

1

20

High-throughput

0.691

High

649329

HP1B3
Heterochromatin protein 1-binding protein 3

1

4

High-throughput

0.691

High

649357

H2A2B
Histone H2A type 2-B

1

20

High-throughput

0.691

High

649360

H18
Histone H1.8

1

3

High-throughput

0.691

High

649361

H2B3B
Histone H2B type 3-B

1

20

High-throughput

0.691

High

649326

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.665

High

649385

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.665

High

649400

H2B1N
Histone H2B type 1-N

1

20

High-throughput

0.665

High

649402

H2B1M
Histone H2B type 1-M

1

20

High-throughput

0.665

High

649340

CC137
Coiled-coil domain-containing protein 137

3

2

High-throughput

0.662

High

175595

SR140
U2 snRNP-associated SURP motif-containing protein

2

7

High-throughput

0.628

High

257747

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

2

5

High-throughput

0.628

High

649273

MECP2
Methyl-CpG-binding protein 2

2

7

High-throughput

0.628

High

649286

RL30
Large ribosomal subunit protein eL30

2

1

High-throughput

0.628

High

649300

ZNF92
Zinc finger protein 92

2

6

High-throughput

0.628

High

649308

PRP4K
Serine/threonine-protein kinase PRP4 homolog

2

20

High-throughput

0.628

High

649312

NOG2
Nucleolar GTP-binding protein 2

2

4

High-throughput

0.628

High

649314

DHX8
ATP-dependent RNA helicase DHX8

2

6

High-throughput

0.628

High

649320

TTF1
Transcription termination factor 1

2

5

High-throughput

0.628

High

649331

RSBN1
Lysine-specific demethylase 9

2

5

High-throughput

0.628

High

649349

ZN771
Zinc finger protein 771

2

14

High-throughput

0.628

High

649351

BHA15
Class A basic helix-loop-helix protein 15

2

2

High-throughput

0.628

High

649352

ZCCHV
Zinc finger CCCH-type antiviral protein 1

2

13

High-throughput

0.628

High

649359

SRRM1
Serine/arginine repetitive matrix protein 1

2

10

High-throughput

0.628

High

649367

ZC3H8
Zinc finger CCCH domain-containing protein 8

2

8

High-throughput

0.628

High

649376

DDX54
ATP-dependent RNA helicase DDX54

2

8

High-throughput

0.628

High

649393

ZN668
Zinc finger protein 668

2

10

High-throughput

0.628

High

649395

YTDC1
YTH domain-containing protein 1

2

6

High-throughput

0.628

High

649397

PURB
Transcriptional regulator protein Pur-beta

2

8

High-throughput

0.628

High

649405

BUD13
BUD13 homolog

2

8

High-throughput

0.628

High

649415

GTPB4
GTP-binding protein 4

2

2

High-throughput

0.628

High

649417

NAT10
RNA cytidine acetyltransferase

2

3

High-throughput

0.628

High

649426

SFR19
Splicing factor, arginine/serine-rich 19

2

15

High-throughput

0.628

High

649438

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

2

8

High-throughput

0.628

High

649459

YBOX2
Y-box-binding protein 2

2

20

High-throughput

0.628

High

256770

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

633997

H2A1D
Histone H2A type 1-D

1

20

High-throughput

0.618

High

649324

H31T
Histone H3.1t

1

20

High-throughput

0.618

High

649335

H2A2A
Histone H2A type 2-A

1

20

High-throughput

0.618

High

649337

H3C
Histone H3.3C

1

20

High-throughput

0.618

High

649347

H32
Histone H3.2

1

20

High-throughput

0.618

High

649350

H2A3
Histone H2A type 3

1

20

High-throughput

0.618

High

649384

H2A1C
Histone H2A type 1-C

1

20

High-throughput

0.618

High

649394

H2A1H
Histone H2A type 1-H

1

20

High-throughput

0.618

High

649401

H2A1J
Histone H2A type 1-J

1

20

High-throughput

0.618

High

649327

LARP7
La-related protein 7

2

20

High-throughput

0.611

High

649386

RL36L
Ribosomal protein eL42-like

2

4

High-throughput

0.611

High

649409

NOC4L
Nucleolar complex protein 4 homolog

3

8

High-throughput

0.604

High

334381

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

5

High-throughput

0.574

High

649266

RS5
Small ribosomal subunit protein uS7

2

5

High-throughput

0.574

High

649267

RS10
Small ribosomal subunit protein eS10

2

5

High-throughput

0.574

High

649274

FGF8
Fibroblast growth factor 8

2

2

High-throughput

0.574

High

649303

ELAV2
ELAV-like protein 2

2

11

High-throughput

0.574

High

649311

KRR1
KRR1 small subunit processome component homolog

2

5

High-throughput

0.574

High

649317

RRS1
Ribosome biogenesis regulatory protein homolog

2

4

High-throughput

0.574

High

649321

PUM3
Pumilio homolog 3

2

5

High-throughput

0.574

High

649328

RRP12
RRP12-like protein

2

4

High-throughput

0.574

High

649338

DHX57
Putative ATP-dependent RNA helicase DHX57

2

20

High-throughput

0.574

High

649362

ZCHC7
Zinc finger CCHC domain-containing protein 7

2

20

High-throughput

0.574

High

649370

KRI1
Protein KRI1 homolog

2

4

High-throughput

0.574

High

649373

NGDN
Neuroguidin

2

6

High-throughput

0.574

High

649375

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

2

11

High-throughput

0.574

High

649377

BRX1
Ribosome biogenesis protein BRX1 homolog

2

19

High-throughput

0.574

High

649380

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

2

4

High-throughput

0.574

High

649381

SRS12
Serine/arginine-rich splicing factor 12

2

13

High-throughput

0.574

High

649391

TOE1
Target of EGR1 protein 1

2

5

High-throughput

0.574

High

649392

DDX27
Probable ATP-dependent RNA helicase DDX27

2

7

High-throughput

0.574

High

649403

CMS1
Protein CMSS1

2

2

High-throughput

0.574

High

649433

ZCC17
Zinc finger CCHC domain-containing protein 17

2

8

High-throughput

0.574

High

649444

TBA8
Tubulin alpha-8 chain

2

1

High-throughput

0.574

High

649461

RBM19
Probable RNA-binding protein 19

2

18

High-throughput

0.574

High

182244

WDR46
WD repeat-containing protein 46

2

11

High-throughput

0.558

High

649454

RL26L
Ribosomal protein uL24-like

2

9

High-throughput

0.558

High

70995

ZN724
Zinc finger protein 724

2

4

High-throughput

0.552

High

182911

NKRF
NF-kappa-B-repressing factor

1

4

High-throughput

0.536

High

188432

NVL
Nuclear valosin-containing protein-like

1

1

High-throughput

0.536

High

191535

MAGB2
Melanoma-associated antigen B2

1

3

High-throughput

0.536

High

192549

NUP42
Nucleoporin NUP42

1

1

High-throughput

0.536

High

284064

SRS10
Serine/arginine-rich splicing factor 10

1

9

High-throughput

0.536

High

485566

RU2A
U2 small nuclear ribonucleoprotein A'

1

6

High-throughput

0.536

High

586522

RS2
Small ribosomal subunit protein uS5

1

5

High-throughput

0.536

High

649259

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.536

High

649265

RAGP1
Ran GTPase-activating protein 1

1

4

High-throughput

0.536

High

649276

RS3A
Small ribosomal subunit protein eS1

1

4

High-throughput

0.536

High

649278

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.536

High

649282

RS15
Small ribosomal subunit protein uS19

1

6

High-throughput

0.536

High

649283

RS24
Small ribosomal subunit protein eS24

1

3

High-throughput

0.536

High

649288

RL10A
Large ribosomal subunit protein uL1

1

9

High-throughput

0.536

High

649290

TRA2B
Transformer-2 protein homolog beta

1

17

High-throughput

0.536

High

649292

YBOX1
Y-box-binding protein 1

1

20

High-throughput

0.536

High

649296

SET
Protein SET

1

5

High-throughput

0.536

High

649299

RL6
Large ribosomal subunit protein eL6

1

4

High-throughput

0.536

High

649301

SRSF1
Serine/arginine-rich splicing factor 1

1

15

High-throughput

0.536

High

649302

TP53B
TP53-binding protein 1

1

9

High-throughput

0.536

High

649304

DDX10
Probable ATP-dependent RNA helicase DDX10

1

13

High-throughput

0.536

High

649307

SF3B2
Splicing factor 3B subunit 2

1

4

High-throughput

0.536

High

649310

TRA2A
Transformer-2 protein homolog alpha

1

5

High-throughput

0.536

High

649315

ZN460
Zinc finger protein 460

1

10

High-throughput

0.536

High

649322

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

12

High-throughput

0.536

High

649343

LN28B
Protein lin-28 homolog B

1

20

High-throughput

0.536

High

649344

SRCAP
Helicase SRCAP

1

8

High-throughput

0.536

High

649346

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

10

High-throughput

0.536

High

649353

ZN467
Zinc finger protein 467

1

9

High-throughput

0.536

High

649378

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

6

High-throughput

0.536

High

649383

RENT1
Regulator of nonsense transcripts 1

1

8

High-throughput

0.536

High

649389

NEIL1
Endonuclease 8-like 1

1

1

High-throughput

0.536

High

649398

NP1L4
Nucleosome assembly protein 1-like 4

1

5

High-throughput

0.536

High

649404

MBB1A
Myb-binding protein 1A

1

2

High-throughput

0.536

High

649416

REXO4
RNA exonuclease 4

1

8

High-throughput

0.536

High

649431

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.536

High

649432

MOV10
Helicase MOV-10

1

8

High-throughput

0.536

High

649434

DMAP1
DNA methyltransferase 1-associated protein 1

1

1

High-throughput

0.536

High

649435

PRD10
PR domain zinc finger protein 10

1

18

High-throughput

0.536

High

649443

LYAR
Cell growth-regulating nucleolar protein

1

2

High-throughput

0.536

High

649445

DDX56
Probable ATP-dependent RNA helicase DDX56

1

9

High-throughput

0.536

High

649451

ZBT47
Zinc finger and BTB domain-containing protein 47

1

14

High-throughput

0.536

High

649455

SRPK3
SRSF protein kinase 3

1

12

High-throughput

0.536

High

649460

NOC2L
Nucleolar complex protein 2 homolog

1

2

High-throughput

0.536

High

451481

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.513

High

649261

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

649269

RM19
Large ribosomal subunit protein bL19m

1

0

High-throughput

0.513

High

649279

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.513

High

649366

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.513

High

649429

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.513

High

649447

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.513

High

649442

IRAK4
Interleukin-1 receptor-associated kinase 4

1

5

Small-scale

0.501

High

140542

MPP10
U3 small nucleolar ribonucleoprotein protein MPP10

1

4

High-throughput

0.489

High

208179

RRP8
Ribosomal RNA-processing protein 8

1

5

High-throughput

0.489

High

288583

NPM3
Nucleoplasmin-3

1

5

High-throughput

0.489

High

300921

RL1D1
Ribosomal L1 domain-containing protein 1

1

9

High-throughput

0.489

High

464111

TPM2
Tropomyosin beta chain

1

1

High-throughput

0.489

High

477754

RM03
Large ribosomal subunit protein uL3m

1

5

High-throughput

0.489

High

649262

RS19
Small ribosomal subunit protein eS19

1

5

High-throughput

0.489

High

649264

RBM34
RNA-binding protein 34

1

9

High-throughput

0.489

High

649272

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.489

High

649287

RL31
Large ribosomal subunit protein eL31

1

4

High-throughput

0.489

High

649289

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.489

High

649305

SRSF9
Serine/arginine-rich splicing factor 9

1

15

High-throughput

0.489

High

649306

SRSF6
Serine/arginine-rich splicing factor 6

1

19

High-throughput

0.489

High

649309

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

4

High-throughput

0.489

High

649313

FGFP1
Fibroblast growth factor-binding protein 1

1

1

High-throughput

0.489

High

649319

WDR43
WD repeat-containing protein 43

1

11

High-throughput

0.489

High

649330

SPOUT
28S rRNA

1

1

High-throughput

0.489

High

649356

PNM8A
Paraneoplastic antigen-like protein 8A

1

2

High-throughput

0.489

High

649358

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

9

High-throughput

0.489

High

649364

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

20

High-throughput

0.489

High

649379

THAP3
THAP domain-containing protein 3

1

3

High-throughput

0.489

High

649382

LAR4B
La-related protein 4B

1

14

High-throughput

0.489

High

649396

UIF
UAP56-interacting factor

1

3

High-throughput

0.489

High

649399

EBP2
Probable rRNA-processing protein EBP2

1

3

High-throughput

0.489

High

649407

UTP23
rRNA-processing protein UTP23 homolog

1

6

High-throughput

0.489

High

649408

WDR18
WD repeat-containing protein 18

1

11

High-throughput

0.489

High

649412

RM09
Large ribosomal subunit protein bL9m

1

2

High-throughput

0.489

High

649419

RM18
Large ribosomal subunit protein uL18m

1

1

High-throughput

0.489

High

649420

GZF1
GDNF-inducible zinc finger protein 1

1

11

High-throughput

0.489

High

649425

RPF2
Ribosome production factor 2 homolog

1

3

High-throughput

0.489

High

649439

DDX21
Nucleolar RNA helicase 2

1

6

High-throughput

0.489

High

649446

RM39
Large ribosomal subunit protein mL39

1

1

High-throughput

0.489

High

649452

NOL12
Nucleolar protein 12

1

2

High-throughput

0.489

High

649458

DDX52
Probable ATP-dependent RNA helicase DDX52

1

1

High-throughput

0.489

High

222721

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

240756

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

324530

HEXI1
Protein HEXIM1

1

4

High-throughput

0.479

High

330661

KI20A
Kinesin-like protein KIF20A

1

15

High-throughput

0.479

High

331628

MBD4
Methyl-CpG-binding domain protein 4

1

1

Small-scale

0.479

High

371169

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

405790

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

482312

F16P1
Fructose-1,6-bisphosphatase 1

1

2

High-throughput

0.479

High

504858

H2AB2
Histone H2A-Bbd type 2/3

1

20

High-throughput

0.479

High

550119

PABP1
Polyadenylate-binding protein 1

1

9

High-throughput

0.479

High

649260

1433T
14-3-3 protein theta

1

10

High-throughput

0.479

High

649263

RL3
Large ribosomal subunit protein uL3

1

4

High-throughput

0.479

High

649268

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

649270

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

649271

GSK3B
Glycogen synthase kinase-3 beta

1

12

High-throughput

0.479

High

649277

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.479

High

649280

H4
Histone H4

1

7

High-throughput

0.479

High

649285

RBX1
E3 ubiquitin-protein ligase RBX1

1

4

High-throughput

0.479

High

649297

KIF23
Kinesin-like protein KIF23

1

9

High-throughput

0.479

High

649318

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

649348

MEPCE
7SK snRNA methylphosphate capping enzyme

1

4

High-throughput

0.479

High

649354

SLN11
Schlafen family member 11

1

3

Small-scale

0.479

High

649371

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

649414

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.479

High

649418

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

5

Small-scale

0.479

High

649422

CHM4B
Charged multivesicular body protein 4b

1

7

High-throughput

0.479

High

649427

ECT2
Protein ECT2

1

7

High-throughput

0.479

High

649463

SETBP
SET-binding protein

1

0

High-throughput

0.458

High

603164

KPCA
Protein kinase C alpha type

1

18

Small-scale

0.457

High

649275

RRP1
Ribosomal RNA processing protein 1 homolog A

1

2

High-throughput

0.445

High

649284

RS30
Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

1

10

High-throughput

0.445

High

649291

1433Z
14-3-3 protein zeta/delta

1

10

High-throughput

0.445

High

649316

CBX2
Chromobox protein homolog 2

1

15

High-throughput

0.445

High

649323

T22D1
TSC22 domain family protein 1

1

6

Small-scale

0.445

High

649334

SPT2
Protein SPT2 homolog

1

2

High-throughput

0.445

High

649341

ATAD2
ATPase family AAA domain-containing protein 2

1

2

High-throughput

0.445

High

649342

F111B
Serine protease FAM111B

1

3

High-throughput

0.445

High

649421

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

20

High-throughput

0.445

High

649424

DHX33
ATP-dependent RNA helicase DHX33

1

6

High-throughput

0.445

High

649430

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

7

High-throughput

0.445

High

649441

RNF12
E3 ubiquitin-protein ligase RLIM

1

2

High-throughput

0.445

High

649450

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

11

High-throughput

0.445

High

649456

SCAF8
SR-related and CTD-associated factor 8

1

2

High-throughput

0.445

High

649457

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

6

High-throughput

0.445

High

156960

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.437

High

338054

NSA2
Ribosome biogenesis protein NSA2 homolog

1

3

High-throughput

0.437

High

460432

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

3

High-throughput

0.437

High

649332

FBW10
F-box/WD repeat-containing protein 10

1

11

High-throughput

0.437

High

649436

ANLN
Anillin

1

3

High-throughput

0.437

High

649372

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.426

High

72756

B0UZZ8
WD repeat-containing protein 46

1

11

High-throughput

0.407

High

161779

RIOK3
Serine/threonine-protein kinase RIO3

1

4

High-throughput

0.407

High

649294

NOP14
Nucleolar protein 14

1

2

High-throughput

0.407

High

649336

MRM1
rRNA methyltransferase 1, mitochondrial

1

2

High-throughput

0.407

High

649339

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

4

High-throughput

0.407

High

649355

PATL1
Protein PAT1 homolog 1

1

1

High-throughput

0.407

High

649365

SRBD1
S1 RNA-binding domain-containing protein 1

1

4

High-throughput

0.407

High

649374

DDX55
ATP-dependent RNA helicase DDX55

1

13

High-throughput

0.407

High

649410

NUSAP
Nucleolar and spindle-associated protein 1

1

1

High-throughput

0.407

High

649423

ESF1
ESF1 homolog

1

1

High-throughput

0.407

High

649453

UTP16
U3 small nucleolar RNA-associated protein NOL7

1

1

High-throughput

0.407

High

649437

NPDC1
Neural proliferation differentiation and control protein 1

3

0

High-throughput

0.347

High

649448

RM35
Large ribosomal subunit protein bL35m

2

0

High-throughput

0.313

High

649333

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

649368

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.279

Low

649369

RM43
Large ribosomal subunit protein mL43

1

0

High-throughput

0.279

Low

649390

RM48
Large ribosomal subunit protein mL48

1

0

High-throughput

0.279

Low

649406

LLPH
Protein LLP homolog

1

0

High-throughput

0.279

Low

649411

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.279

Low

649413

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.279

Low

649440

RT18A
Large ribosomal subunit protein mL66

1

0

High-throughput

0.279

Low

649449

RM27
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.279

Low

649462

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.279

Low

649363

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.249

Low

649345

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.232

Low

649388

CSTOS
Protein CUSTOS

1

0

High-throughput

0.232

Low

649428

ANKZ1
tRNA endonuclease ANKZF1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025