HitPredict

Interactor 1: CADH1 (P12830)
Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3]
Gene: CDH1

Interactor 2: PTPRS (Q13332)
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
Gene: PTPRS

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21126580
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0030517 - negative regulation of axon extension GO:0070062 - extracellular exosome GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 882 Hs			1 1948
+	Hs
		489891 CADH1_HUMAN (1-882): 0: 836: 100.00		PTPRF_HUMAN (1-1948): 0: 1528: 65.42
+	Hs
		490028 PCDBG_HUMAN (376-868): 1.94e-73: 258: 16.96		PTPRF_HUMAN (1-1948): 0: 1528: 65.42
+	Hs
		521728 CADH1_HUMAN (1-882): 0: 836: 100.00		PTPRG_HUMAN (858-1945): 0: 786: 25.86
+	Hs
		576981 CADH2_HUMAN (28-881): 0: 769: 45.86		PTPRA_HUMAN (1176-1948): 0: 815: 39.54
+	Hs
		580201 CADH2_HUMAN (28-881): 0: 769: 45.86		PTPRG_HUMAN (858-1945): 0: 786: 25.86
+	Hs
		521727 CADH1_HUMAN (1-882): 0: 836: 100.00		PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51
+	Hs
		521898 CADH1_HUMAN (1-882): 0: 836: 100.00		PTPRJ_HUMAN (1651-1945): 1.75e-106: 375: 37.29
+	Mm
		454946 CADH1_MOUSE (1-882): 0: 799: 81.45		PTPRM_MOUSE (266-1652): 9.81e-103: 365: 17.06
+	Hs
		580229 CADH2_HUMAN (28-881): 0: 769: 45.86		PTPRJ_HUMAN (1651-1945): 1.75e-106: 375: 37.29
+	Hs
		441173 CADH2_HUMAN (28-881): 0: 769: 45.86		PTPRC_HUMAN (450-1662): 1.43e-85: 311: 15.29
+	Hs
		616974 DSC3_HUMAN (2-874): 0: 655: 27.92		PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51
+	Mm
		454937 CADH1_MOUSE (1-882): 0: 799: 81.45		PTPRQ_MOUSE (575-1447): 2.68e-45: 183: 15.00
+	Mm
		472760 CADH2_MOUSE (28-881): 0: 762: 46.43		PTPRQ_MOUSE (575-1447): 2.68e-45: 183: 15.00
+	Hs
		580200 CADH2_HUMAN (28-881): 0: 769: 45.86		PTPRB_HUMAN (257-1309): 2.07e-37: 157: 12.51
+	Hs
		521743 CADH1_HUMAN (1-882): 0: 836: 100.00		PTPRM_HUMAN (33-462): 1.68e-09: 65.4: 12.86
+	Hs
		580235 CADH2_HUMAN (28-881): 0: 769: 45.86		PTPRK_HUMAN (113-670): 1.42e-10: 68.9: 15.72
+	Hs
		617023 PCDBG_HUMAN (376-868): 1.94e-73: 258: 16.96		PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51
+	Hs
		617033 PCDB6_HUMAN (382-868): 1.26e-67: 242: 15.76		PTPRD_HUMAN (4-1463): 1.86e-106: 381: 16.51
+	Hs
		616903 CADH5_HUMAN (30-511): 8.2e-52: 196: 20.91		PTPRB_HUMAN (257-1309): 2.07e-37: 157: 12.51
+	Hs
		1269195 PCDB7_HUMAN (385-867): 7.31e-69: 246: 15.22		PTPRU_HUMAN (211-781): 3.44e-19: 97.4: 14.71