Interactor 1: PEP5 (P12868)
E3 ubiquitin-protein ligase PEP5 (EC 2.3.2.27) (Carboxypeptidase Y-deficient protein 5) (Histone E3 ligase PEP5) (RING-type E3 ubiquitin transferase PEP5) (Vacuolar biogenesis protein END1) (Vacuolar morphogenesis protein 1) (Vacuolar protein sorting-associated protein 11) (Vacuolar protein-targeting protein 11)
Gene: PEP5

Interactor 2: VAM6 (Q07468)
Vacuolar morphogenesis protein 6 (Vacuolar protein sorting-associated protein 39)
Gene: VAM6

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 0.60 0.761

The method score is based on:

Property Details
Experiments 11283351, 10944212, 11062257, 16429126, 21325627, 20604902, 25026036, 15889152, 27852901, 29870720, 37574178, 37968396, 22940862
Identification Methods two hybrid pooling approach, affinity chromatography technology, two hybrid, biochemical, pull down, anti bait coimmunoprecipitation, tandem affinity purification
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0000329 - fungal-type vacuole membrane
GO:0006886 - intracellular protein transport
GO:0007033 - vacuole organization
GO:0030897 - HOPS complex
GO:0035542 - regulation of SNARE complex assembly
and 2 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 1029
Sc

1 1049
+ Sc
+ Sc
+ Sc
+ Hs
+ Hs
+ Hs
+ Sc
+ Hs
+ Zm
+ Hs

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Last updated: 15 Jul 2024