Protein: ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)

Gene: ODP2, LAT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 148
UniProt ID: P12695

Gene Ontology (top 5):
GO:0004742 - dihydrolipoyllysine-residue acetyltransferase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006086 - pyruvate decarboxylation to acetyl-CoA
GO:0045254 - pyruvate dehydrogenase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554894

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

6

8

High-throughput

0.943

High

554874

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

5

13

High-throughput

0.919

High

554875

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

3

17

High-throughput

0.827

High

484706

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

2

16

High-throughput

0.754

High

554884

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

3

2

High-throughput

0.660

High

554900

PREP
Presequence protease, mitochondrial

2

9

High-throughput

0.621

High

554877

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

17

High-throughput

0.618

High

554910

MIC60
MICOS complex subunit MIC60

2

1

High-throughput

0.584

High

554936

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

453386

PYR1
Multifunctional protein URA2

1

5

High-throughput

0.575

High

525769

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

554893

HS104
Heat shock protein 104

2

4

Small-scale

0.533

High

554901

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.521

High

522880

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.504

High

533151

GPA2
Guanine nucleotide-binding protein alpha-2 subunit

1

1

High-throughput

0.500

High

554879

FKBP
FK506-binding protein 1

1

1

High-throughput

0.500

High

554930

RSP5
E3 ubiquitin-protein ligase RSP5

1

5

High-throughput

0.500

High

554916

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.479

High

554923

MLH1
DNA mismatch repair protein MLH1

1

0

High-throughput

0.479

High

394018

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.479

High

458524

SEC4
Ras-related protein SEC4

1

3

Small-scale

0.479

High

514409

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

554878

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

554899

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

554904

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.479

High

554927

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

1

High-throughput

0.479

High

554953

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

554966

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

1

High-throughput

0.479

High

554984

SMC6
Structural maintenance of chromosomes protein 6

1

4

High-throughput

0.479

High

554881

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

554920

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.458

High

554922

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

Small-scale

0.458

High

554942

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

509364

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.457

High

364284

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.457

High

440888

CDC7
Cell division control protein 7

1

4

High-throughput

0.457

High

554868

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.457

High

554870

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.457

High

554871

ABP1
Actin-binding protein

1

3

High-throughput

0.457

High

554880

DBF2
Cell cycle protein kinase DBF2

1

4

High-throughput

0.457

High

554891

RAD16
DNA repair protein RAD16

1

3

High-throughput

0.457

High

554892

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

2

High-throughput

0.457

High

554898

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

7

High-throughput

0.457

High

554915

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.457

High

554924

TEM1
Protein TEM1

1

8

High-throughput

0.457

High

554926

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.457

High

554933

FKH1
Fork head protein homolog 1

1

2

High-throughput

0.457

High

554945

BOL2
BolA-like protein 2

1

1

High-throughput

0.457

High

554947

BUD32
EKC/KEOPS complex subunit BUD32

1

1

High-throughput

0.457

High

554951

IPI3
Pre-rRNA-processing protein IPI3

1

7

High-throughput

0.457

High

554955

CDC14
Tyrosine-protein phosphatase CDC14

1

2

High-throughput

0.457

High

554957

COFI
Cofilin

1

1

High-throughput

0.457

High

554981

LAS17
Proline-rich protein LAS17

1

2

High-throughput

0.457

High

394168

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.445

High

554934

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

383473

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

427109

RLA0
Large ribosomal subunit protein uL10

1

1

Small-scale

0.437

High

433402

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

434762

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.437

High

441659

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.437

High

454825

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

502801

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

503999

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

512214

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

554873

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

554885

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.437

High

554888

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

554889

TF3B
Transcription factor IIIB 70 kDa subunit

1

2

High-throughput

0.437

High

554895

SPT16
FACT complex subunit SPT16

1

2

High-throughput

0.437

High

554906

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

554907

IF4B
Eukaryotic translation initiation factor 4B

1

1

High-throughput

0.437

High

554909

DEF1
RNA polymerase II degradation factor 1

1

4

High-throughput

0.437

High

554911

NOP4
Nucleolar protein 4

1

1

High-throughput

0.437

High

554912

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.437

High

554918

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

554929

RCY1
Recyclin-1

1

1

High-throughput

0.437

High

554940

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

554949

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

554954

ORC1
Origin recognition complex subunit 1

1

2

High-throughput

0.437

High

554956

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.437

High

554958

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.437

High

554959

ESC1
Silent chromatin protein ESC1

1

1

High-throughput

0.437

High

554962

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

554965

POB3
FACT complex subunit POB3

1

2

High-throughput

0.437

High

554971

SEC10
Exocyst complex component SEC10

1

1

Small-scale

0.437

High

554975

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

554979

ARP8
Actin-like protein ARP8

1

2

High-throughput

0.437

High

554980

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

554982

RUVB2
RuvB-like protein 2

1

2

High-throughput

0.437

High

554983

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.437

High

364894

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.407

High

386540

TBB
Tubulin beta chain

1

3

High-throughput

0.407

High

485997

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.407

High

543626

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.407

High

554872

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

554876

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.407

High

554883

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.407

High

554921

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.407

High

554932

6P21
6-phosphofructo-2-kinase 1

1

1

High-throughput

0.407

High

554935

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

554973

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.407

High

554908

UBX1
UBX domain-containing protein 1

2

0

Small-scale

0.318

High

554867

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.310

High

554946

PESC
Pescadillo homolog

2

0

High-throughput

0.310

High

550612

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

554869

UBC4
Ubiquitin-conjugating enzyme E2 4

1

0

High-throughput

0.261

Low

554882

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

554886

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.261

Low

554890

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.261

Low

554897

GYP6
GTPase-activating protein GYP6

1

0

High-throughput

0.261

Low

554913

AP3M
AP-3 complex subunit mu

1

0

High-throughput

0.261

Low

554917

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

0

High-throughput

0.261

Low

554943

RL37B
Large ribosomal subunit protein eL37B

1

0

High-throughput

0.261

Low

554948

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.261

Low

554952

DMA2
E3 ubiquitin-protein ligase DMA2

1

0

High-throughput

0.261

Low

554976

DDC1
DNA damage checkpoint protein 1

1

0

High-throughput

0.261

Low

149544

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

268861

MRP10
Small ribosomal subunit protein mS37

1

0

High-throughput

0.249

Low

435726

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

548811

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.249

Low

554887

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

554896

IES6
Chromatin-remodeling complex subunit IES6

1

0

High-throughput

0.249

Low

554902

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

554905

SPC29
Spindle pole component 29

1

0

High-throughput

0.249

Low

554914

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

554919

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

554928

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

554938

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

554939

HGH1
Protein HGH1

1

0

Small-scale

0.249

Low

554941

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

554944

NBP1
NAP1-binding protein

1

0

High-throughput

0.249

Low

554961

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.249

Low

554963

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

554964

PDR15
ATP-dependent permease PDR15

1

0

High-throughput

0.249

Low

554969

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

554970

PEX30
Peroxisomal membrane protein PEX30

1

0

Small-scale

0.249

Low

554972

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

554974

ENB1
Siderophore iron transporter ENB1

1

0

High-throughput

0.249

Low

554977

NIP7
60S ribosome subunit biogenesis protein NIP7

1

0

High-throughput

0.249

Low

554978

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

554903

VPS17
Vacuolar protein sorting-associated protein 17

1

0

High-throughput

0.232

Low

554925

MNN9
Mannan polymerase complexes subunit MNN9

1

0

High-throughput

0.232

Low

554931

SHO1
High osmolarity signaling protein SHO1

1

0

High-throughput

0.232

Low

554937

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low

554950

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.232

Low

554960

YMB8
Uncharacterized vacuolar membrane protein YML018C

1

0

High-throughput

0.232

Low

554967

YD338
Uncharacterized transporter YDR338C

1

0

High-throughput

0.232

Low

554968

NSE3
Non-structural maintenance of chromosome element 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025