HitPredict

Interactor 1: SRC (P12931)
Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
Gene: SRC

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.970

The method score is based on:

Property Details
Experiments 12857726, 9600099, 17092689, 15866871, 17974954, 16115959, 16537444, 11007774
Identification Methods affinity chromatography technology, enzymatic study, coimmunoprecipitation, bimolecular fluorescence complementation, phosphatase assay, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type physical association, direct interaction, association, dephosphorylation reaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Y_phosphatase, SH2~Y_phosphatase
Common GO terms GO:0005158 - insulin receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0019899 - enzyme binding
GO:0045296 - cadherin binding
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 15 Jul 2024