Protein: PTPRS
Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)

Gene: PTPRS
Organism: Homo sapiens
Interactions: 165
UniProt ID: Q13332

Gene Ontology (top 5):
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1102706

NTRK3
NT-3 growth factor receptor

4

20

Small-scale

0.899

High

378082

TNFA
Tumor necrosis factor

3

2

High-throughput

0.861

High

627523

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

3

1

High-throughput

0.861

High

788912

TGFR2
TGF-beta receptor type-2

3

6

High-throughput

0.861

High

1095523

LIPA1
Liprin-alpha-1

3

11

Small-scale

0.845

High

1102701

I13R2
Interleukin-13 receptor subunit alpha-2

2

19

High-throughput

0.811

High

658881

PTPRD
Receptor-type tyrosine-protein phosphatase delta

2

17

Small-scale

0.800

High

761218

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.789

High

484127

PGFRB
Platelet-derived growth factor receptor beta

2

16

High-throughput

0.776

High

596478

CTLA4
Cytotoxic T-lymphocyte protein 4

2

4

High-throughput

0.776

High

71383

HECA2
HEPACAM family member 2

3

19

High-throughput

0.770

High

1102710

CEA21
Cell adhesion molecule CEACAM21

3

17

High-throughput

0.770

High

749326

TNFL8
Tumor necrosis factor ligand superfamily member 8

2

0

High-throughput

0.770

High

1102708

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

17

Small-scale

0.740

High

62116

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

9

High-throughput

0.726

High

939491

FCGRN
IgG receptor FcRn large subunit p51

2

5

High-throughput

0.726

High

1102741

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

4

High-throughput

0.726

High

283683

GPC4
Glypican-4

1

8

Small-scale

0.724

High

1102697

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.698

High

282837

CRLF1
Cytokine receptor-like factor 1

1

19

High-throughput

0.691

High

658822

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

20

High-throughput

0.691

High

731841

CEAM8
Cell adhesion molecule CEACAM8

1

16

High-throughput

0.691

High

1006899

KC1G2
Casein kinase I isoform gamma-2

1

4

High-throughput

0.691

High

1102696

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.691

High

469715

MMP3
Stromelysin-1

4

1

High-throughput

0.691

High

378595

EPO
Erythropoietin

1

0

High-throughput

0.656

High

659721

OMGP
Oligodendrocyte-myelin glycoprotein

1

6

Small-scale

0.647

High

906273

GPC3
Glypican-3

1

8

Small-scale

0.647

High

1102725

GPC2
Glypican-2 [Cleaved into: Secreted glypican-2]

1

8

Small-scale

0.647

High

1102743

SLIK1
SLIT and NTRK-like protein 1

1

3

Small-scale

0.647

High

1102782

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

8

Small-scale

0.647

High

533657

CLUS
Clusterin

2

2

High-throughput

0.628

High

1102716

S39A5
Zinc transporter ZIP5

2

3

High-throughput

0.628

High

1102738

ARRD3
Arrestin domain-containing protein 3

2

4

High-throughput

0.628

High

1102739

MRAP2
Melanocortin-2 receptor accessory protein 2

2

2

High-throughput

0.628

High

1102760

PCD12
Protocadherin-12

2

20

High-throughput

0.628

High

1102776

PCDGD
Protocadherin gamma-B1

2

19

High-throughput

0.628

High

271623

LIPA3
Liprin-alpha-3

1

11

Small-scale

0.621

High

276369

LIPA2
Liprin-alpha-2

1

13

Small-scale

0.621

High

1102770

OPT
Opticin

1

7

High-throughput

0.618

High

299541

TRIO
Triple functional domain protein

1

2

High-throughput

0.618

High

363225

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

410813

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.618

High

411867

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

466235

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

522657

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

17

High-throughput

0.618

High

601268

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

774328

BASI
Basigin

1

11

High-throughput

0.618

High

787157

BMR1A
Bone morphogenetic protein receptor type-1A

1

6

High-throughput

0.618

High

845625

MUC18
Cell surface glycoprotein MUC18

1

16

High-throughput

0.618

High

910035

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.618

High

953423

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

955122

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

962011

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

977977

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

988333

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1022578

PKD1
Polycystin-1

1

4

Small-scale

0.618

High

1102705

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1102719

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

1102754

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

1102755

TM231
Transmembrane protein 231

3

1

High-throughput

0.609

High

1102780

LIPG
Endothelial lipase

2

0

High-throughput

0.602

High

286651

STX11
Syntaxin-11

2

3

High-throughput

0.601

High

602892

INAR1
Interferon alpha/beta receptor 1

2

19

High-throughput

0.601

High

1102771

FBX2
F-box only protein 2

2

10

High-throughput

0.601

High

1102784

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

3

High-throughput

0.601

High

1102704

RAB35
Ras-related protein Rab-35

1

5

High-throughput

0.590

High

1102750

TMM59
Transmembrane protein 59

2

0

High-throughput

0.576

High

262224

SCN2B
Sodium channel regulatory subunit beta-2

1

8

High-throughput

0.575

High

440539

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.575

High

541467

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.575

High

1102709

MICB
MHC class I polypeptide-related sequence B

1

6

High-throughput

0.575

High

1102727

LRC52
Leucine-rich repeat-containing protein 52

1

4

High-throughput

0.575

High

1102730

LIRB4
Leukocyte immunoglobulin-like receptor subfamily B member 4

1

6

High-throughput

0.575

High

1102756

MANS1
MANSC domain-containing protein 1

2

1

High-throughput

0.574

High

964261

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.560

High

1102728

RN149
E3 ubiquitin-protein ligase RNF149

2

8

High-throughput

0.558

High

1102721

LRRT4
Leucine-rich repeat transmembrane neuronal protein 4

1

6

Small-scale

0.553

High

1102734

CSKI2
Caskin-2

1

7

High-throughput

0.553

High

1102694

PTPRS
Receptor-type tyrosine-protein phosphatase S

1

17

Small-scale

0.545

High

636729

PTN
Pleiotrophin

1

3

High-throughput

0.541

High

687992

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

1102723

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.541

High

139652

DLL1
Delta-like protein 1

1

3

High-throughput

0.536

High

275809

CAD16
Cadherin-16

1

20

High-throughput

0.536

High

663494

PRPH2
Peripherin-2

1

6

High-throughput

0.536

High

1102707

SGCA
Alpha-sarcoglycan

1

2

High-throughput

0.536

High

1102711

CC50B
Cell cycle control protein 50B

1

2

High-throughput

0.536

High

1102715

I20RB
Interleukin-20 receptor subunit beta

1

4

High-throughput

0.536

High

1102724

NRSN1
Neurensin-1

1

1

High-throughput

0.536

High

1102729

ARRD4
Arrestin domain-containing protein 4

1

4

High-throughput

0.536

High

1102731

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

7

High-throughput

0.536

High

1102744

SCN2A
Sodium channel protein type 2 subunit alpha

1

8

High-throughput

0.536

High

1102748

SYT11
Synaptotagmin-11

1

1

High-throughput

0.536

High

1102751

TMPSD
Transmembrane protease serine 13

1

8

High-throughput

0.536

High

1102767

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.536

High

1102772

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

6

High-throughput

0.536

High

1102777

PCDG7
Protocadherin gamma-A7

1

20

High-throughput

0.536

High

1102781

ST14
Suppressor of tumorigenicity 14 protein

1

7

High-throughput

0.536

High

1102783

PTC2
Protein patched homolog 2

1

1

High-throughput

0.536

High

762450

PROF2
Profilin-2

1

0

High-throughput

0.518

High

1102695

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

1102736

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.518

High

1102747

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.518

High

1102749

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.518

High

1102774

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.518

High

1102700

IF4A2
Eukaryotic initiation factor 4A-II

1

2

High-throughput

0.515

High

518839

CCL3
C-C motif chemokine 3

1

0

High-throughput

0.513

High

1101329

SG2A2
Mammaglobin-A

1

1

High-throughput

0.489

High

1102733

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

1

High-throughput

0.489

High

1102752

SE6L1
Seizure 6-like protein

1

4

High-throughput

0.489

High

1102753

CSTL1
Cystatin-like 1

1

3

High-throughput

0.489

High

1102758

UD17
UDP-glucuronosyltransferase 1A7

1

1

High-throughput

0.489

High

130086

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

218145

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

334001

SMC2
Structural maintenance of chromosomes protein 2

1

2

High-throughput

0.479

High

556057

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

1102699

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

1102702

SMC1A
Structural maintenance of chromosomes protein 1A

1

2

High-throughput

0.479

High

1102720

GET4
Golgi to ER traffic protein 4 homolog

1

1

High-throughput

0.479

High

1102735

GCN1
Stalled ribosome sensor GCN1

1

9

High-throughput

0.479

High

1102745

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

1102761

FBX6
F-box only protein 6

1

10

High-throughput

0.479

High

1102762

SMC4
Structural maintenance of chromosomes protein 4

1

2

High-throughput

0.479

High

1102766

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

2

High-throughput

0.479

High

1102737

CCD47
PAT complex subunit CCDC47

1

2

High-throughput

0.470

High

1102768

RRBP1
Ribosome-binding protein 1

1

2

High-throughput

0.470

High

1102779

TF3C3
General transcription factor 3C polypeptide 3

1

1

High-throughput

0.470

High

648152

NDKB
Nucleoside diphosphate kinase B

1

0

Small-scale

0.458

High

255003

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

388405

B3AT
Band 3 anion transport protein

1

2

High-throughput

0.445

High

529738

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

669317

ACKR3
Atypical chemokine receptor 3

1

6

High-throughput

0.445

High

870230

S6A12
Sodium- and chloride-dependent betaine transporter

1

6

High-throughput

0.445

High

870358

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

6

High-throughput

0.445

High

876422

EAA4
Excitatory amino acid transporter 4

1

4

High-throughput

0.445

High

1102698

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

1102722

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

1

High-throughput

0.445

High

1102726

PCD20
Protocadherin-20

1

20

High-throughput

0.445

High

1102742

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

4

High-throughput

0.445

High

1102759

ANKH
Mineralization regulator ANKH

1

1

High-throughput

0.445

High

1102773

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

1102775

PCDGE
Protocadherin gamma-B2

1

20

High-throughput

0.445

High

1102778

PCDG6
Protocadherin gamma-A6

1

20

High-throughput

0.445

High

105865

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

1102717

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

0

High-throughput

0.426

High

1102732

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.426

High

1010029

DLK1
Protein delta homolog 1

1

8

High-throughput

0.407

High

1102714

NPAL3
NIPA-like protein 3

1

4

High-throughput

0.407

High

1102757

ZDH11
Palmitoyltransferase ZDHHC11

1

4

High-throughput

0.407

High

1102764

EVA1B
Protein eva-1 homolog B

1

1

High-throughput

0.407

High

1102765

CLDN1
Claudin domain-containing protein 1

1

2

High-throughput

0.407

High

1102763

GINM1
Glycoprotein integral membrane protein 1

3

0

High-throughput

0.347

High

388525

CRP

3

0

High-throughput

0.345

High

333751

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

0

High-throughput

0.328

High

1088322

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

0

High-throughput

0.282

High

1102703

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.282

High

1102769

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.282

High

1102712

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

1102713

IL31
Interleukin-31

1

0

High-throughput

0.279

Low

1102718

SMIM5
Small integral membrane protein 5

1

0

High-throughput

0.279

Low

1102740

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low

1102746

CGRE1
Cell growth regulator with EF hand domain protein 1

1

0

High-throughput

0.279

Low

869029

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025