HitPredict - High confidence protein-protein interactions

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	30585729, 10750018
Identification Methods	proximity labelling technology, affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ku~Ku, Ku~Ku_C, Ku~Ku_N, Ku_C~Ku_N, Ku_C~SAP, Ku_N~Ku_N, Ku_N~SAP
Common GO terms	GO:0000723 - telomere maintenance GO:0000725 - recombinational repair GO:0000781 - chromosome, telomeric region GO:0000783 - nuclear telomere cap complex GO:0000976 - transcription cis-regulatory region binding and 42 others more... GO:0002218 - activation of innate immune response GO:0003677 - DNA binding GO:0003678 - DNA helicase activity GO:0003684 - damaged DNA binding GO:0003690 - double-stranded DNA binding GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005730 - nucleolus GO:0005829 - cytosol GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex GO:0006266 - DNA ligation GO:0006303 - double-strand break repair via nonhomologous end joining GO:0008094 - ATP-dependent activity, acting on DNA GO:0016020 - membrane GO:0016887 - ATP hydrolysis activity GO:0030332 - cyclin binding GO:0032991 - protein-containing complex GO:0032993 - protein-DNA complex GO:0034774 - secretory granule lumen GO:0042162 - telomeric DNA binding GO:0043564 - Ku70:Ku80 complex GO:0044877 - protein-containing complex binding GO:0045087 - innate immune response GO:0045621 - positive regulation of lymphocyte differentiation GO:0045860 - positive regulation of protein kinase activity GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048660 - regulation of smooth muscle cell proliferation GO:0051575 - 5'-deoxyribose-5-phosphate lyase activity GO:0070418 - DNA-dependent protein kinase complex GO:0070419 - nonhomologous end joining complex GO:0071475 - cellular hyperosmotic salinity response GO:0071480 - cellular response to gamma radiation GO:0071481 - cellular response to X-ray GO:0097110 - scaffold protein binding GO:0097680 - double-strand break repair via classical nonhomologous end joining GO:1904813 - ficolin-1-rich granule lumen
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	609
Hs

1	609

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Last updated: 15 Jul 2024