HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: HDGF (P51858)
Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)
Gene: HDGF

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21907836
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 240
+	Hs
		523618 XRCC6_HUMAN (1-609): 0: 666: 100.00		MSH6_HUMAN (5-232): 3.82e-46: 165: 18.55
+	Hs
		523798 XRCC6_HUMAN (1-609): 0: 666: 100.00		GLYR1_HUMAN (6-228): 2.27e-46: 163: 25.94
+	Hs
		524079 XRCC6_HUMAN (1-609): 0: 666: 100.00		ZMYD8_HUMAN (3-233): 1.74e-41: 152: 20.59
+	Hs
		265951 XRCC6_HUMAN (1-609): 0: 666: 100.00		PSIP1_HUMAN (7-239): 7.38e-38: 140: 37.60
+	Hs
		523845 XRCC6_HUMAN (1-609): 0: 666: 100.00		HDGR2_HUMAN (7-222): 6.08e-26: 107: 36.57
+	Hs
		524845 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		HDGF_HUMAN (1-240): 4.63e-53: 173: 100.00
+	Hs
		524847 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		MSH6_HUMAN (5-232): 3.82e-46: 165: 18.55