HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	0.60	0.608

Property	Details
Experiments	35914814, 36950384
Identification Methods	two hybrid, two hybrid fragment pooling approach, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 763
+	Hs
		414706 XRCC6_HUMAN (1-609): 0: 666: 100.00		CDK1_HUMAN (156-482): 1.29e-121: 368: 26.57
+	Hs
		523528 XRCC6_HUMAN (1-609): 0: 666: 100.00		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		524917 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Hs
		524796 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85