HitPredict

Interactor 1: XRCC6 (P12956)
X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6)
Gene: XRCC6

Interactor 2: PAXI1 (Q6ZW49)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: PAXIP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22990118
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BRCT~Ku, BRCT_2~Ku, BRCT~Ku_C, BRCT_2~Ku_C
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 609 Hs			1 1069
+	Hs
		523752 XRCC6_HUMAN (1-609): 0: 666: 100.00		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Hs
		524009 XRCC6_HUMAN (1-609): 0: 666: 100.00		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Hs
		524050 XRCC6_HUMAN (1-609): 0: 666: 100.00		CHD7_HUMAN (188-893): 7.26e-34: 144: 9.07
+	Hs
		524926 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Hs
		525061 XRCC5_HUMAN (31-609): 5.27e-125: 387: 16.77		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97