Protein: YCFI
Metal resistance protein YCF1 (ABC-type Cd(2+) transporter) (EC 7.2.2.2) (ABC-type glutathione-S-conjugate transporter) (EC 7.6.2.3) (Yeast cadmium factor 1)

Gene: YCFI, YCF1
Organism: Saccharomyces cerevisiae S288C
Interactions: 96
UniProt ID: P39109

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0000329 - fungal-type vacuole membrane
GO:0005524 - ATP binding
GO:0006749 - glutathione metabolic process
GO:0008551 - P-type cadmium transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585940

CSK21
Casein kinase II subunit alpha

2

3

Small-scale

0.757

High

811611

KC13
Casein kinase I homolog 3

1

2

High-throughput

0.733

High

811628

VATG
V-type proton ATPase subunit G

3

2

High-throughput

0.658

High

622954

CSK22
Casein kinase II subunit alpha'

1

3

Small-scale

0.618

High

673294

ADP1
Probable ATP-dependent permease

1

5

High-throughput

0.618

High

736184

YBT1
ATP-dependent bile acid permease

1

8

High-throughput

0.618

High

811610

YCFI
Metal resistance protein YCF1

1

8

Small-scale

0.618

High

808629

AURK
Aurora kinase

1

0

High-throughput

0.614

High

811614

SSB2
Ribosome-associated molecular chaperone SSB2

2

5

High-throughput

0.608

High

808401

HAL5
Serine/threonine-protein kinase HAL5

1

0

Small-scale

0.589

High

811632

KIN4
Serine/threonine-protein kinase KIN4

1

0

Small-scale

0.589

High

365626

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.541

High

376231

RAS2
Ras-like protein 2

1

9

High-throughput

0.532

High

811636

COFI
Cofilin

1

2

High-throughput

0.532

High

448536

RHO1
GTP-binding protein RHO1

1

20

Small-scale

0.527

High

709760

BMH1
Protein BMH1

1

2

High-throughput

0.518

High

365052

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.518

High

811617

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.518

High

403515

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.494

High

604543

PHO81
Phosphate system positive regulatory protein PHO81

1

2

High-throughput

0.494

High

618586

FAS2
Fatty acid synthase subunit alpha

1

2

High-throughput

0.494

High

757653

IF4B
Eukaryotic translation initiation factor 4B

1

1

High-throughput

0.494

High

792052

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.494

High

760533

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

1

Small-scale

0.481

High

547051

PPB
Repressible alkaline phosphatase

1

2

High-throughput

0.479

High

579407

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.479

High

645823

VATE
V-type proton ATPase subunit E

1

1

High-throughput

0.479

High

672664

BPH1
Beige protein homolog 1

1

2

High-throughput

0.479

High

679690

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

693185

PHO91
Low-affinity phosphate transporter PHO91

1

5

High-throughput

0.479

High

740059

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

2

High-throughput

0.479

High

743684

VATD
V-type proton ATPase subunit D

1

2

High-throughput

0.479

High

748743

YPT7
Ypt/Rab-type GTPase YPT7

1

4

Small-scale

0.479

High

810804

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.479

High

811613

VTC1
Vacuolar transporter chaperone complex subunit 1

1

11

High-throughput

0.479

High

811616

TM108
Protein TMA108

1

1

High-throughput

0.479

High

811621

VNX1
Low affinity vacuolar monovalent cation/H(+) antiporter

1

1

High-throughput

0.479

High

811622

VTC2
Vacuolar transporter chaperone complex subunit 2

1

17

High-throughput

0.479

High

811626

VTC4
Vacuolar transporter chaperone complex subunit 4

1

17

High-throughput

0.479

High

811629

VSB1
Vacuolar basic amino acid transporter VSB1

1

3

High-throughput

0.479

High

811635

VTC3
Vacuolar transporter chaperone 3 complex subunit 3

1

17

High-throughput

0.479

High

811637

YMB8
Uncharacterized vacuolar membrane protein YML018C

1

1

High-throughput

0.479

High

811643

VAM3
Syntaxin VAM3

1

1

Small-scale

0.479

High

811627

LSM8
LSM2-LSM8 complex subunit LSM8

1

1

High-throughput

0.464

High

528820

RLA3
Large ribosomal subunit protein P1B

1

0

High-throughput

0.458

High

635038

VPS33
Vacuolar protein sorting-associated protein 33

1

0

Small-scale

0.458

High

671924

RBSK
Ribokinase

1

0

High-throughput

0.458

High

796489

PFF1
Vacuolar membrane protease

1

0

High-throughput

0.458

High

811625

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

392743

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.445

High

523977

HSP71
Heat shock protein SSA1

1

7

High-throughput

0.445

High

526718

HSP72
Heat shock protein SSA2

1

7

High-throughput

0.445

High

544905

SSB1
Ribosome-associated molecular chaperone SSB1

1

5

High-throughput

0.445

High

676007

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

741597

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

506457

U5072
UPF0507 protein YML002W

1

1

Small-scale

0.439

High

811631

NUM1
Nuclear migration protein NUM1

1

1

Small-scale

0.439

High

558725

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

707122

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

794992

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

807759

CSK2C
Casein kinase II subunit beta'

1

1

Small-scale

0.437

High

811623

CSK2B
Casein kinase II subunit beta

1

1

Small-scale

0.437

High

811638

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

811645

CMR1
DNA damage-binding protein CMR1

1

4

High-throughput

0.437

High

358217

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.304

High

811641

TUS1
Rho1 guanine nucleotide exchange factor TUS1

1

0

Small-scale

0.288

High

361439

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.282

High

368669

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.282

High

439340

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.282

High

572587

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.282

High

737372

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.282

High

800897

NCB5R
NADH-cytochrome b5 reductase 1

1

0

High-throughput

0.282

High

806457

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.282

High

809308

STM1
Suppressor protein STM1

1

0

High-throughput

0.282

High

811612

SNU13
13 kDa ribonucleoprotein-associated protein

1

0

High-throughput

0.282

High

811615

YNU8
Uncharacterized protein YNL208W

1

0

High-throughput

0.282

High

811619

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.282

High

811624

ARC1
tRNA-aminoacylation cofactor ARC1

1

0

High-throughput

0.282

High

811634

NACB1
Nascent polypeptide-associated complex subunit beta-1

1

0

High-throughput

0.282

High

811647

TMA7
Translation machinery-associated protein 7

1

0

High-throughput

0.282

High

811618

GTS1
Protein GTS1

1

0

Small-scale

0.251

Low

811620

MPG1
Mannose-1-phosphate guanyltransferase

1

0

Small-scale

0.251

Low

811640

RGC1
Regulator of the glycerol channel 1

1

0

Small-scale

0.251

Low

536022

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

0

High-throughput

0.249

Low

575040

CDC26
Anaphase-promoting complex subunit CDC26

1

0

High-throughput

0.249

Low

627086

RM44
Large ribosomal subunit protein mL53

1

0

High-throughput

0.249

Low

744265

CHAC
Glutathione-specific gamma-glutamylcyclotransferase

1

0

High-throughput

0.249

Low

780750

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

798441

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.249

Low

811630

YG36
Uncharacterized protein YGR126W

1

0

High-throughput

0.249

Low

811633

ADPP
ADP-ribose pyrophosphatase

1

0

High-throughput

0.249

Low

811639

RM34
Large ribosomal subunit protein bL34m

1

0

High-throughput

0.249

Low

811642

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.249

Low

811646

YL363
Uncharacterized protein YLR363W-A

1

0

High-throughput

0.249

Low

811644

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025