HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: DNLI4 (P49917)
DNA ligase 4 (EC 6.5.1.1) (DNA ligase IV) (Polydeoxyribonucleotide synthase [ATP] 4)
Gene: LIG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

The method score is based on:

Property	Details
Experiments	26774286, 15520013, 10757784
Identification Methods	affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	BRCT~Ku, BRCT~Ku_C, DNA_ligase_A_C~Ku_N, DNA_ligase_A_N~Ku_N
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0003677 - DNA binding GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 6 others more... GO:0005958 - DNA-dependent protein kinase-DNA ligase 4 complex GO:0006302 - double-strand break repair GO:0006303 - double-strand break repair via nonhomologous end joining GO:0022008 - neurogenesis GO:0050769 - positive regulation of neurogenesis GO:0070419 - nonhomologous end joining complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	732
Hs

1	911

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024