Protein: PURA2
Adenylosuccinate synthetase isozyme 2 (AMPSase 2) (AdSS 2) (EC 6.3.4.4) (Adenylosuccinate synthetase, acidic isozyme) (Adenylosuccinate synthetase, liver isozyme) (L-type adenylosuccinate synthetase) (IMP--aspartate ligase 2)

Gene: PURA2, ADSS2
Organism: Homo sapiens
Interactions: 92
UniProt ID: P30520

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0002376 - immune system process
GO:0004019 - adenylosuccinate synthase activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720124

PURA1
Adenylosuccinate synthetase isozyme 1

5

3

High-throughput

0.916

High

720125

SMYD1
Histone-lysine N-methyltransferase SMYD1

4

0

High-throughput

0.679

High

720089

LEG7
Galectin-7

2

0

High-throughput

0.585

High

720094

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.584

High

240853

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

289241

SPB7
Serpin B7

1

0

High-throughput

0.513

High

720113

CUL3
Cullin-3

1

0

High-throughput

0.513

High

720120

SBSN
Suprabasin

1

0

High-throughput

0.513

High

720130

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

720133

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

720140

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

379900

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

409281

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.479

High

532392

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

550872

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.479

High

690761

1433T
14-3-3 protein theta

1

2

High-throughput

0.479

High

720083

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

720086

IF4A3
Eukaryotic initiation factor 4A-III

1

1

High-throughput

0.479

High

720088

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

720103

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

720106

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.479

High

720121

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

720122

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

1

High-throughput

0.479

High

258773

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.458

High

270318

WDR1
WD repeat-containing protein 1

1

0

High-throughput

0.458

High

293261

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

370159

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

376730

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

412934

CPNS1
Calpain small subunit 1

1

0

High-throughput

0.458

High

415377

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.458

High

420386

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

502249

H2A1
Histone H2A type 1

1

0

High-throughput

0.458

High

536582

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

562562

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.458

High

565788

EF2
Elongation factor 2

1

0

High-throughput

0.458

High

615642

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.458

High

657989

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

716402

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

720085

TALDO
Transaldolase

1

0

High-throughput

0.458

High

720087

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

720090

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.458

High

720092

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.458

High

720093

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.458

High

720095

DEST
Destrin

1

0

High-throughput

0.458

High

720096

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

720097

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.458

High

720098

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

720099

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

720100

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.458

High

720101

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

720102

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.458

High

720104

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

720105

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

720107

H31
Histone H3.1

1

0

High-throughput

0.458

High

720109

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

720111

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

720112

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.458

High

720114

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

720115

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.458

High

720116

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

720118

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

720126

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

720127

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

720129

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

720134

ATG10
Ubiquitin-like-conjugating enzyme ATG10

1

0

High-throughput

0.458

High

720137

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.458

High

720138

TR150
Thyroid hormone receptor-associated protein 3

1

0

High-throughput

0.458

High

587998

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

720110

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

127005

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

369161

OAS1
2'-5'-oligoadenylate synthase 1

1

0

High-throughput

0.426

High

529172

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

720119

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

720123

DND1
Dead end protein homolog 1

1

0

High-throughput

0.426

High

720132

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

720135

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

720136

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

720128

NPB
Neuropeptide B

2

0

High-throughput

0.328

High

720091

KLK7
Kallikrein-7

1

0

High-throughput

0.279

Low

720117

CDSN
Corneodesmosin

1

0

High-throughput

0.279

Low

720131

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

105419

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

142854

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.249

Low

259504

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

353021

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

371267

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

642650

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

694709

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720084

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

720108

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.249

Low

330054

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

720139

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025