HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: PDX1 (P52945)
Pancreas/duodenum homeobox protein 1 (PDX-1) (Glucose-sensitive factor) (GSF) (Insulin promoter factor 1) (IPF-1) (Insulin upstream factor 1) (IUF-1) (Islet/duodenum homeobox-1) (IDX-1) (Somatostatin-transactivating factor 1) (STF-1)
Gene: PDX1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16166097
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0009410 - response to xenobiotic stimulus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 283
+	Hs
		446887 XRCC5_HUMAN (1-732): 0: 755: 100.00		HXC4_HUMAN (74-244): 8.7e-37: 133: 34.07
+	Hs
		453045 XRCC5_HUMAN (1-732): 0: 755: 100.00		HXB7_HUMAN (7-216): 6.62e-37: 132: 28.10
+	Hs
		524803 XRCC5_HUMAN (1-732): 0: 755: 100.00		TLX1_HUMAN (74-246): 3.9e-34: 128: 27.75
+	Hs
		523620 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		PDX1_HUMAN (1-283): 8.9e-50: 167: 100.00
+	Hs
		446886 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		HXC4_HUMAN (74-244): 8.7e-37: 133: 34.07
+	Hs
		453044 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		HXB7_HUMAN (7-216): 6.62e-37: 132: 28.10
+	Hs
		446861 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		HXD4_HUMAN (105-206): 3.18e-36: 131: 48.04
+	Hs
		523542 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		TLX1_HUMAN (74-246): 3.9e-34: 128: 27.75
+	Hs
		523686 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		EMX2_HUMAN (3-219): 2.06e-30: 116: 21.88
+	Mm
		291993 XRCC6_MOUSE (3-627): 7.65e-138: 420: 14.09		LMX1B_MOUSE (104-275): 1.05e-29: 117: 18.61