HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.989

The method score is based on:

Property Details
Experiments 26496610, 26446488, 9312071, 33005030, 12393188, 10446239, 35031618, 30017584, 37071682, 15520013, 15758953, 21679440, 10750018, 16857680, 28154079, 28345663, 15941674, 35271311, 22404984, 20023628 and 3 others

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Identification Methods affinity chromatography technology, pull down, cross-linking study, enzymatic study, x-ray crystallography, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DNA-PKcs_N~Ku, DNA-PKcs_N~Ku_C, DNAPKcs_CC5~Ku_N, DNAPKcs_CC1-2~Ku_PK_bind
Common GO terms GO:0000723 - telomere maintenance
GO:0000781 - chromosome, telomeric region
GO:0002218 - activation of innate immune response
GO:0003690 - double-stranded DNA binding
GO:0003723 - RNA binding
and 19 others

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Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 732
Hs

1 4128
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024