HitPredict

Interactor 1: XRCC5 (P13010)
X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining))
Gene: XRCC5

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29049411, 30110629, 33742100
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol and 1 others more... GO:0032993 - protein-DNA complex
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 732 Hs			1 2414
+	Hs
		523699 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		525116 XRCC5_HUMAN (1-732): 0: 755: 100.00		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		525080 XRCC5_HUMAN (1-732): 0: 755: 100.00		BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31
+	Hs
		525104 XRCC5_HUMAN (1-732): 0: 755: 100.00		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		524926 XRCC5_HUMAN (1-732): 0: 755: 100.00		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		524997 XRCC5_HUMAN (1-732): 0: 755: 100.00		PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86
+	Hs
		524031 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31
+	Hs
		523701 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86
+	Hs
		524050 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		CHD7_HUMAN (69-452): 4.51e-13: 77.9: 12.02
+	Hs
		523752 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82
+	Hs
		523911 XRCC6_HUMAN (3-609): 3.61e-141: 429: 14.49		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25