HitPredict

Interactor 1: TDGF1 (P13385)
Protein Cripto (Cripto, EGF-CFC family member) (Cripto-1 growth factor) (CRGF) (Epidermal growth factor-like cripto protein CR1) (Teratocarcinoma-derived growth factor 1)
Gene: CRIPTO

Interactor 2: AVR2A (P27037)
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)
Gene: ACVR2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28126904
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007368 - determination of left/right symmetry GO:0009952 - anterior/posterior pattern specification GO:0009986 - cell surface
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 188 Hs			1 513
+	Hs
		526889 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		AVR2B_HUMAN (4-513): 2.64e-141: 418: 67.12
+	Hs
		526879 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		BMR1A_HUMAN (59-488): 2.92e-128: 385: 33.41
+	Hs
		526881 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		TGFR2_HUMAN (28-493): 8.82e-123: 372: 33.79
+	Hs
		526890 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		BMPR2_HUMAN (5-502): 7.76e-116: 367: 32.89
+	Mm
		646091 TDGF1_MOUSE (6-182): 2.3e-99: 286: 67.23		AVR2B_MOUSE (4-513): 1.8e-137: 409: 64.42
+	Hs
		526886 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		ACVR1_HUMAN (47-493): 6.71e-117: 355: 30.27
+	Hs
		526880 TDGF1_HUMAN (1-188): 2.42e-120: 339: 100.00		ACV1B_HUMAN (2-488): 1.4e-113: 346: 28.41